{"id":128,"title":"Kidney dysfunction by decreased thyroid hormone","short_name":"Kidney dysfunction","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-04-29T16:02:57.000-04:00","corresponding_author":{"id":585,"created_at":"2018-03-20T08:57:53.000-04:00","updated_at":"2026-06-09T03:31:28.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":277,"event":"Thyroid hormone synthesis, Decreased","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"},{"event_id":813,"event":"Increased, Serum creatinine","event_type":"KeyEvent"},{"event_id":823,"event":"Occurrence, Cystic dilatation (renal tubule)","event_type":"KeyEvent"},{"event_id":824,"event":"Occurrence, Cytoplasmic vacuolization (podocyte)","event_type":"KeyEvent"},{"event_id":818,"event":"Occurrence, Cytoplasmic vacuolization (Renal tubule)","event_type":"KeyEvent"},{"event_id":819,"event":"Decreased, Glomerular filtration","event_type":"KeyEvent"},{"event_id":820,"event":"Decreased, Renal plasma flow","event_type":"KeyEvent"},{"event_id":821,"event":"Decreased, Sodium reabsorption","event_type":"KeyEvent"},{"event_id":825,"event":"Decreased, Renal ability to dilute urine","event_type":"KeyEvent"}],"aop_aos":[{"event_id":814,"event":"Occurrence, Kidney toxicity","event_type":"AdverseOutcome"}],"relationships":[{"relation":2805,"upstream_event_id":277,"upstream_event":"Thyroid hormone synthesis, Decreased","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":2806,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":818,"downstream_event":"Occurrence, Cytoplasmic vacuolization (Renal tubule)"},{"relation":2807,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":823,"downstream_event":"Occurrence, Cystic dilatation (renal 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