| November 02, 2021 14:18 |
Nathalie Delrue |
Oecd Status changed from EAGMST Under Review to WPHA/WNT Endorsed. |
| July 06, 2021 08:07 |
Takumi Ohishi |
Considerations for Potential Applications of the AOP updated. |
| July 06, 2021 08:05 |
Takumi Ohishi |
Considerations for Potential Applications of the AOP updated. |
| July 02, 2021 04:01 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| July 02, 2021 03:59 |
Takumi Ohishi |
Abstract updated. |
| June 27, 2021 08:14 |
Takumi Ohishi |
Considerations for Potential Applications of the AOP updated. |
| June 27, 2021 02:08 |
Takumi Ohishi |
Quantitative Considerations updated. |
| June 27, 2021 01:49 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| June 27, 2021 01:44 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| June 27, 2021 01:41 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| June 27, 2021 01:25 |
Takumi Ohishi |
Overall Assessment of the AOP updated. |
| June 27, 2021 01:19 |
Takumi Ohishi |
Background updated. |
| June 24, 2021 07:28 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| June 24, 2021 07:22 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| June 24, 2021 06:56 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| June 24, 2021 03:39 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| June 24, 2021 03:37 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| June 24, 2021 03:32 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| June 24, 2021 03:27 |
Takumi Ohishi |
Essentiality of the Key Events updated. |
| June 24, 2021 02:58 |
Takumi Ohishi |
Background updated. |
| June 24, 2021 02:56 |
Takumi Ohishi |
Domain of Applicability and Background updated. |
| June 24, 2021 02:50 |
Takumi Ohishi |
Domain of Applicability updated. |
| June 24, 2021 02:48 |
Takumi Ohishi |
Background updated. |
| June 24, 2021 02:44 |
Takumi Ohishi |
Overall Assessment of the AOP and Background updated. |
| June 24, 2021 02:20 |
Takumi Ohishi |
Stressor:163 - Evidence text updated. |
| June 24, 2021 02:18 |
Takumi Ohishi |
Background updated. |
| June 24, 2021 02:15 |
Takumi Ohishi |
Abstract updated. |
| September 17, 2020 19:11 |
Takumi Ohishi |
Sex term: Unspecific - Evidence changed from Not Specified to High. |
| September 17, 2020 08:09 |
Takumi Ohishi |
Sex term: Mixed was removed from AOP. |
| September 17, 2020 08:09 |
Takumi Ohishi |
Sex term: Unspecific was added to AOP. |
| April 06, 2020 02:48 |
Takumi Ohishi |
Abstract updated. |
| April 06, 2020 02:47 |
Takumi Ohishi |
Overall Assessment of the AOP updated. |
| March 25, 2020 01:29 |
Kiyoshi Kushima |
Abstract updated. |
| March 23, 2020 20:47 |
Takumi Ohishi |
Essentiality of the Key Events updated. |
| March 20, 2020 23:56 |
Takumi Ohishi |
Quantitative Considerations updated. |
| March 20, 2020 23:46 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 20, 2020 23:37 |
Takumi Ohishi |
References updated. |
| March 20, 2020 23:26 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 20, 2020 23:24 |
Takumi Ohishi |
References updated. |
| March 20, 2020 23:16 |
Takumi Ohishi |
References updated. |
| March 20, 2020 22:55 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 20, 2020 22:44 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 20, 2020 22:29 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 20, 2020 22:14 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 20, 2020 22:04 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 20, 2020 21:45 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 20, 2020 21:40 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 20, 2020 20:30 |
Takumi Ohishi |
Considerations for Potential Applications of the AOP updated. |
| March 20, 2020 20:13 |
Takumi Ohishi |
Domain of Applicability updated. |
| March 20, 2020 05:00 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 20, 2020 04:30 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 20, 2020 03:08 |
Takumi Ohishi |
Domain of Applicability and Considerations for Potential Applications of the AOP updated. |
| March 20, 2020 02:51 |
Takumi Ohishi |
Domain of Applicability updated. |
| March 20, 2020 02:39 |
Takumi Ohishi |
Stressor:535 was added to AOP. |
| March 20, 2020 02:38 |
Takumi Ohishi |
Stressor:534 was added to AOP. |
| March 20, 2020 02:37 |
Takumi Ohishi |
Stressor:533 was added to AOP. |
| March 20, 2020 02:36 |
Takumi Ohishi |
Stressor:532 was added to AOP. |
| March 20, 2020 02:34 |
Takumi Ohishi |
Stressor:531 was added to AOP. |
| March 20, 2020 02:31 |
Takumi Ohishi |
Stressor:530 was added to AOP. |
| March 20, 2020 02:29 |
Takumi Ohishi |
Stressor:529 was added to AOP. |
| March 17, 2020 07:38 |
Takumi Ohishi |
References updated. |
| March 17, 2020 07:37 |
Takumi Ohishi |
Abstract, Domain of Applicability, Considerations for Potential Applications of the AOP, References, and Background updated. |
| March 14, 2020 01:35 |
Takumi Ohishi |
Essentiality of the Key Events updated. |
| March 14, 2020 01:34 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 14, 2020 01:15 |
Takumi Ohishi |
Weight of Evidence Summary updated. |
| March 14, 2020 01:11 |
Takumi Ohishi |
Essentiality of the Key Events updated. |
| March 14, 2020 00:47 |
Takumi Ohishi |
Essentiality of the Key Events updated. |
| March 14, 2020 00:41 |
Takumi Ohishi |
Essentiality of the Key Events updated. |
| March 14, 2020 00:27 |
Takumi Ohishi |
Background updated. |
| March 13, 2020 23:23 |
Takumi Ohishi |
Considerations for Potential Applications of the AOP updated. |
| March 13, 2020 23:18 |
Takumi Ohishi |
Considerations for Potential Applications of the AOP updated. |
| March 13, 2020 23:07 |
Takumi Ohishi |
Considerations for Potential Applications of the AOP updated. |
| March 13, 2020 23:02 |
Takumi Ohishi |
Overall Assessment of the AOP updated. |
| March 13, 2020 22:53 |
Takumi Ohishi |
Overall Assessment of the AOP updated. |
| March 13, 2020 22:48 |
Takumi Ohishi |
Taxonomic term: Rattus norvegicus - Evidence changed from null to High. |
| March 13, 2020 22:47 |
Takumi Ohishi |
Stressor:294 - Evidence changed from null to High. |
| March 13, 2020 22:46 |
Takumi Ohishi |
Stressor:163 - Evidence changed from null to High. |
| March 13, 2020 22:44 |
Takumi Ohishi |
Relationship:1508 - Evidence changed from High to Moderate. Quantitative understanding changed from High to Moderate. |
| March 13, 2020 22:41 |
Takumi Ohishi |
Abstract updated. |
| December 16, 2019 01:14 |
Kiyoshi Kushima |
Authors updated. |
| January 29, 2019 18:11 |
Kiyoshi Kushima |
Weight of Evidence Summary, Quantitative Considerations, Considerations for Potential Applications of the AOP, References, and Overall Assessment of the AOP updated. |
| January 29, 2019 18:03 |
Kiyoshi Kushima |
Abstract updated. |
| May 31, 2018 07:10 |
Kiyoshi Kushima |
Weight of Evidence Summary updated. |
| May 28, 2018 03:02 |
Kiyoshi Kushima |
Abstract, Domain of Applicability, Essentiality of the Key Events, Weight of Evidence Summary, Quantitative Considerations, Considerations for Potential Applications of the AOP, and Overall Assessment of the AOP updated. |
| November 09, 2017 02:44 |
Kiyoshi Kushima |
Quantitative Considerations and Considerations for Potential Applications of the AOP updated. |
| November 09, 2017 02:35 |
Kiyoshi Kushima |
Weight of Evidence Summary updated. |
| November 09, 2017 02:05 |
Kiyoshi Kushima |
Essentiality of the Key Events updated. |
| November 09, 2017 02:02 |
Kiyoshi Kushima |
Domain of Applicability updated. |
| November 09, 2017 02:02 |
Kiyoshi Kushima |
Overall Assessment of the AOP updated. |
| November 09, 2017 01:56 |
Kiyoshi Kushima |
Abstract updated. |
| November 01, 2017 20:28 |
Kiyoshi Kushima |
Domain of Applicability, Weight of Evidence Summary, and Considerations for Potential Applications of the AOP updated. |
| November 01, 2017 20:20 |
Kiyoshi Kushima |
Background updated. |
| October 27, 2017 03:53 |
Kiyoshi Kushima |
|
| October 27, 2017 03:35 |
Kiyoshi Kushima |
Relationship:1508 - Evidence changed from null to Strong. Quantitative understanding changed from null to Strong. |
| October 27, 2017 03:34 |
Kiyoshi Kushima |
Relationship:1508 was added to AOP. |
| October 27, 2017 03:33 |
Kiyoshi Kushima |
Event:980 was added to AOP. |
| October 27, 2017 03:32 |
Kiyoshi Kushima |
Event:980 was removed from AOP. |
| October 27, 2017 03:32 |
Kiyoshi Kushima |
Relationship:1508 was removed from AOP. |
| October 27, 2017 03:32 |
Kiyoshi Kushima |
Event:1201 was removed from AOP. |
| October 27, 2017 03:31 |
Kiyoshi Kushima |
Event:1201 was added to AOP. |
| October 27, 2017 03:28 |
Kiyoshi Kushima |
Event:1201 was removed from AOP. |
| October 27, 2017 03:28 |
Kiyoshi Kushima |
Relationship:1253 was removed from AOP. |
| October 27, 2017 02:27 |
Kiyoshi Kushima |
Quantitative Considerations updated. |
| October 27, 2017 02:26 |
Kiyoshi Kushima |
Weight of Evidence Summary updated. |
| October 27, 2017 02:12 |
Kiyoshi Kushima |
Weight of Evidence Summary updated. |
| October 26, 2017 22:29 |
Kiyoshi Kushima |
References updated. |
| October 25, 2017 23:01 |
Kiyoshi Kushima |
Abstract, Domain of Applicability, Essentiality of the Key Events, Considerations for Potential Applications of the AOP, Overall Assessment of the AOP, and Background updated. |
| May 21, 2017 19:32 |
Kiyoshi Kushima |
Weight of Evidence Summary updated. |
| May 21, 2017 19:29 |
Kiyoshi Kushima |
Taxonomic term: Rattus norvegicus was added to AOP. |
| May 21, 2017 19:28 |
Kiyoshi Kushima |
Taxonomic term: Macaca fascicularis was added to AOP. |
| May 21, 2017 19:27 |
Kiyoshi Kushima |
Taxonomic term: Mus musculus was added to AOP. |
| May 21, 2017 19:27 |
Kiyoshi Kushima |
Taxonomic term: Homo sapiens was added to AOP. |
| May 21, 2017 19:27 |
Kiyoshi Kushima |
Taxonomic term: Since FK506-induced outcomes in humans are mimicked by similar responses in a variety of animal models, immunosuppression induced by FK506-FKPBP12 complexes are considered to be preserved across a variety of mammalian species. was removed from AOP. |
| May 21, 2017 19:25 |
Kiyoshi Kushima |
Abstract updated. |
| May 19, 2017 10:20 |
Kiyoshi Kushima |
Stressor:294 was added to AOP. |
| May 19, 2017 10:17 |
Kiyoshi Kushima |
|
| May 19, 2017 10:15 |
Kiyoshi Kushima |
|
| May 19, 2017 10:13 |
Kiyoshi Kushima |
|
| May 19, 2017 10:05 |
Kiyoshi Kushima |
Relationship:1510 was added to AOP. |
| May 19, 2017 09:59 |
Kiyoshi Kushima |
Relationship:1509 was added to AOP. |
| May 19, 2017 09:53 |
Kiyoshi Kushima |
Relationship:1017 was added to AOP. |
| May 19, 2017 09:52 |
Kiyoshi Kushima |
Abstract, Essentiality of the Key Events, Weight of Evidence Summary, Quantitative Considerations, References, Overall Assessment of the AOP, and Background updated. |
| May 19, 2017 02:55 |
Kiyoshi Kushima |
Relationship:1508 was added to AOP. |
| May 19, 2017 02:50 |
Kiyoshi Kushima |
Relationship:1253 was added to AOP. |
| May 19, 2017 02:49 |
Kiyoshi Kushima |
Relationship:1253 was removed from AOP. |
| May 19, 2017 02:20 |
Kiyoshi Kushima |
Event:1203 was removed from AOP. |
| May 19, 2017 02:20 |
Kiyoshi Kushima |
Event:1204 was removed from AOP. |
| May 19, 2017 02:20 |
Kiyoshi Kushima |
Event:985 was removed from AOP. |
| May 19, 2017 02:20 |
Kiyoshi Kushima |
Event:986 was removed from AOP. |
| May 19, 2017 02:20 |
Kiyoshi Kushima |
Relationship:1254 was removed from AOP. |
| May 19, 2017 02:20 |
Kiyoshi Kushima |
Relationship:1255 was removed from AOP. |
| May 19, 2017 02:19 |
Kiyoshi Kushima |
Relationship:1017 was removed from AOP. |
| May 19, 2017 02:19 |
Kiyoshi Kushima |
Relationship:1256 was removed from AOP. |
| May 19, 2017 02:19 |
Kiyoshi Kushima |
Relationship:1257 was removed from AOP. |
| May 19, 2017 02:19 |
Kiyoshi Kushima |
Relationship:1021 was removed from AOP. |
| May 19, 2017 02:18 |
Kiyoshi Kushima |
Relationship:1258 was removed from AOP. |
| May 19, 2017 02:18 |
Kiyoshi Kushima |
Relationship:1259 was removed from AOP. |
| May 19, 2017 02:18 |
Kiyoshi Kushima |
Relationship:1022 was removed from AOP. |
| May 18, 2017 08:48 |
Kiyoshi Kushima |
Relationship:1260 was removed from AOP. |
| May 18, 2017 08:11 |
Kiyoshi Kushima |
Title, Abstract, Authors, Domain of Applicability, Essentiality of the Key Events, Weight of Evidence Summary, Quantitative Considerations, Overall Assessment of the AOP, and Background updated. |
| April 07, 2017 01:21 |
Kiyoshi Kushima |
|
| April 07, 2017 00:42 |
Kiyoshi Kushima |
|
| February 06, 2017 07:13 |
Nathalie Delrue |
Status changed from Under development: Not open for comment. Do not cite to Open for comment. Do not cite. |
| January 23, 2017 09:04 |
Stephen Edwards |
Oecd Status changed from Under Development to EAGMST Under Review. |
| December 02, 2016 13:47 |
Stephen Edwards |
Abstract, Authors, Domain of Applicability, Weight of Evidence Summary, and References updated. |
| December 02, 2016 13:46 |
Stephen Edwards |
|