{"id":405,"title":"Organo-Phosphate Chemicals induced inhibition of AChE  leading to impaired cognitive function","short_name":"Organo-Phosphate Chemicals leading to impaired cognitive function","created_at":"2021-06-24T16:59:59.000-04:00","updated_at":"2023-04-29T16:03:04.000-04:00","corresponding_author":{"id":1529,"created_at":"2020-05-02T15:51:11.000-04:00","updated_at":"2023-08-03T13:00:22.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":43,"stressor_name":"Organophosphates"},{"stressor_id":649,"stressor_name":"Paraoxon"},{"stressor_id":650,"stressor_name":"Methyl parathion"},{"stressor_id":651,"stressor_name":"Ethyl Parathion"},{"stressor_id":80,"stressor_name":"N-methyl Carbamates"}],"aop_mies":[{"event_id":12,"event":"Acetylcholinesterase (AchE) Inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":10,"event":"Acetylcholine accumulation in synapses","event_type":"KeyEvent"},{"event_id":39,"event":"Increased Cholinergic Signaling","event_type":"KeyEvent"},{"event_id":386,"event":"Decrease of neuronal network function","event_type":"KeyEvent"}],"aop_aos":[{"event_id":402,"event":"Cognitive function, decreased ","event_type":"AdverseOutcome"}],"relationships":[{"relation":2715,"upstream_event_id":12,"upstream_event":"Acetylcholinesterase (AchE) Inhibition","downstream_event_id":10,"downstream_event":"Acetylcholine accumulation in synapses"},{"relation":2718,"upstream_event_id":386,"upstream_event":"Decrease of neuronal network function","downstream_event_id":402,"downstream_event":"Cognitive function, decreased "},{"relation":2716,"upstream_event_id":10,"upstream_event":"Acetylcholine accumulation in synapses","downstream_event_id":39,"downstream_event":"Increased Cholinergic Signaling"},{"relation":2719,"upstream_event_id":39,"upstream_event":"Increased Cholinergic Signaling","downstream_event_id":402,"downstream_event":"Cognitive function, decreased "},{"relation":2717,"upstream_event_id":39,"upstream_event":"Increased Cholinergic Signaling","downstream_event_id":386,"downstream_event":"Decrease of neuronal network function"}]}