{"id":413,"title":"Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure","short_name":"Oxidation of Reduced Glutathione Leading to Mortality","created_at":"2021-08-05T13:59:48.000-04:00","updated_at":"2025-11-28T09:07:12.000-05:00","corresponding_author":{"id":4763,"created_at":"2021-05-19T16:05:35.000-04:00","updated_at":"2021-07-06T16:52:36.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":664,"stressor_name":"Uranium"},{"stressor_id":635,"stressor_name":"Arsenic"},{"stressor_id":665,"stressor_name":"Bis(2,4,6-trimethylphenyl)-lambda~2~-germane--selenium (1/1)"}],"aop_mies":[{"event_id":926,"event":"Oxidation, Glutathione (To be considered with MIE)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"KeyEvent"},{"event_id":1445,"event":"Increase, Lipid peroxidation","event_type":"KeyEvent"},{"event_id":1607,"event":"Increase, Necrosis","event_type":"KeyEvent"},{"event_id":759,"event":"Increased, Kidney Failure","event_type":"KeyEvent"}],"aop_aos":[{"event_id":351,"event":"Increased Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":2793,"upstream_event_id":926,"upstream_event":"Oxidation, Glutathione (To be considered with MIE)","downstream_event_id":1115,"downstream_event":"Increase, Reactive oxygen species"},{"relation":2794,"upstream_event_id":1115,"upstream_event":"Increase, Reactive oxygen species","downstream_event_id":1445,"downstream_event":"Increase, Lipid peroxidation"},{"relation":2795,"upstream_event_id":1445,"upstream_event":"Increase, Lipid peroxidation","downstream_event_id":1607,"downstream_event":"Increase, Necrosis"},{"relation":2796,"upstream_event_id":1607,"upstream_event":"Increase, Necrosis","downstream_event_id":759,"downstream_event":"Increased, Kidney Failure"},{"relation":2797,"upstream_event_id":759,"upstream_event":"Increased, Kidney Failure","downstream_event_id":351,"downstream_event":"Increased Mortality"}]}