{"id":486,"title":"Binding to the extracellular protein laminin leading to decreased cognitive function","short_name":"Binding to laminin and DNT","created_at":"2023-02-21T12:07:43.000-05:00","updated_at":"2023-04-29T16:03:07.000-04:00","corresponding_author":{"id":9061,"created_at":"2022-02-16T08:01:58.000-05:00","updated_at":"2026-03-25T13:51:59.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":760,"stressor_name":"Lei Gong Teng (Common Threewingnut Root)"},{"stressor_id":638,"stressor_name":"(-)-Epigallocatechin gallate"}],"aop_mies":[{"event_id":2109,"event":"Binding, extracellular matrix protein laminin","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2110,"event":"Disrupted binding, laminin-beta1-integrin receptors with laminin","event_type":"KeyEvent"},{"event_id":2111,"event":"Decreased, neural progenitor cell adhesion to laminin","event_type":"KeyEvent"},{"event_id":2112,"event":"Disturbed, radial glia cell alignment and migration","event_type":"KeyEvent"},{"event_id":2113,"event":"Decreased, radial glia cell density","event_type":"KeyEvent"},{"event_id":2114,"event":"Disturbed, cortical architecture","event_type":"KeyEvent"}],"aop_aos":[{"event_id":402,"event":"Cognitive function, decreased ","event_type":"AdverseOutcome"}],"relationships":[]}