{"id":517,"title":"Pregnane X Receptor (PXR) activation leads to liver steatosis","short_name":"PXR activation leads to liver steatosis","created_at":"2023-11-30T15:00:45.000-05:00","updated_at":"2024-10-30T15:14:35.000-04:00","corresponding_author":{"id":17529,"created_at":"2023-05-10T14:47:26.000-04:00","updated_at":"2026-08-11T09:04:29.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":239,"event":"Activation, Pregnane-X receptor, NR1I2","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":54,"event":"Up Regulation, CD36","event_type":"KeyEvent"},{"event_id":115,"event":"Increase, Fatty acid influx","event_type":"KeyEvent"},{"event_id":291,"event":"Accumulation, Triglyceride","event_type":"KeyEvent"}],"aop_aos":[{"event_id":459,"event":"Increase, Liver steatosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":3699,"upstream_event_id":239,"upstream_event":"Activation, Pregnane-X receptor, NR1I2","downstream_event_id":54,"downstream_event":"Up Regulation, CD36"},{"relation":3700,"upstream_event_id":54,"upstream_event":"Up Regulation, CD36","downstream_event_id":115,"downstream_event":"Increase, Fatty acid influx"},{"relation":3701,"upstream_event_id":115,"upstream_event":"Increase, Fatty acid influx","downstream_event_id":291,"downstream_event":"Accumulation, Triglyceride"},{"relation":3741,"upstream_event_id":291,"upstream_event":"Accumulation, Triglyceride","downstream_event_id":459,"downstream_event":"Increase, Liver steatosis"}]}