{"id":524,"title":"Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals ","short_name":"Gluten-driven immune activation leading to celiac disease","created_at":"2024-03-07T03:05:49.000-05:00","updated_at":"2025-07-04T10:31:41.000-04:00","corresponding_author":{"id":18025,"created_at":"2024-02-06T03:17:44.000-05:00","updated_at":"2025-06-17T10:25:37.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":837,"stressor_name":"Gluten"},{"stressor_id":838,"stressor_name":"Bacterial or viral Infections"},{"stressor_id":839,"stressor_name":"Tissue transglutaminase 2 (TG2) enzyme activity"}],"aop_mies":[{"event_id":2252,"event":"Human leukocyte antigen DQ2/8-gluten complexes, formation","event_type":"MolecularInitiatingEvent"},{"event_id":2253,"event":"Gluten-reactive T cell receptors, generation","event_type":"MolecularInitiatingEvent"},{"event_id":2254,"event":"Gluten-reactive and transglutaminase 2 reactive B cell receptors, generation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2275,"event":"Gluten reactive adaptive T-cells with antigen presenting cells, co-localization","event_type":"KeyEvent"},{"event_id":2255,"event":"Innate immune response, activation","event_type":"KeyEvent"},{"event_id":2260,"event":"Gluten-reactive CD4+ T cells, activation","event_type":"KeyEvent"},{"event_id":2256,"event":"Gluten-reactive B cells and transglutaminase 2-reactive B cells, activation","event_type":"KeyEvent"},{"event_id":1931,"event":"Intestinal barrier, disruption","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2257,"event":"Celiac disease","event_type":"AdverseOutcome"}],"relationships":[{"relation":4107,"upstream_event_id":2252,"upstream_event":"Human leukocyte antigen DQ2/8-gluten complexes, formation","downstream_event_id":2275,"downstream_event":"Gluten reactive adaptive T-cells with antigen presenting cells, co-localization"},{"relation":4108,"upstream_event_id":2254,"upstream_event":"Gluten-reactive and transglutaminase 2 reactive B cell receptors, generation","downstream_event_id":2275,"downstream_event":"Gluten reactive adaptive T-cells with antigen presenting cells, co-localization"},{"relation":4109,"upstream_event_id":2253,"upstream_event":"Gluten-reactive T cell receptors, generation","downstream_event_id":2275,"downstream_event":"Gluten reactive adaptive T-cells with antigen presenting cells, co-localization"},{"relation":4110,"upstream_event_id":2275,"upstream_event":"Gluten reactive adaptive T-cells with antigen presenting cells, co-localization","downstream_event_id":2255,"downstream_event":"Innate immune response, activation"},{"relation":4111,"upstream_event_id":2255,"upstream_event":"Innate immune response, activation","downstream_event_id":2260,"downstream_event":"Gluten-reactive CD4+ T cells, activation"},{"relation":4043,"upstream_event_id":2260,"upstream_event":"Gluten-reactive CD4+ T cells, activation","downstream_event_id":2256,"downstream_event":"Gluten-reactive B cells and transglutaminase 2-reactive B cells, activation"},{"relation":4044,"upstream_event_id":2256,"upstream_event":"Gluten-reactive B cells and transglutaminase 2-reactive B cells, activation","downstream_event_id":1931,"downstream_event":"Intestinal barrier, disruption"},{"relation":4048,"upstream_event_id":1931,"upstream_event":"Intestinal barrier, disruption","downstream_event_id":2257,"downstream_event":"Celiac disease"}]}