{"id":599,"title":"Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death","short_name":"ROS leading to growth inhibition via fatty acid oxidation and cell injury/death","created_at":"2025-09-08T04:35:29.000-04:00","updated_at":"2025-09-12T02:31:15.000-04:00","corresponding_author":{"id":322,"created_at":"2016-06-30T07:13:47.000-04:00","updated_at":"2026-09-02T05:43:30.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"},{"event_id":1767,"event":"Increase, Protein oxidation","event_type":"KeyEvent"},{"event_id":179,"event":"Decrease, Fatty acid beta-oxidation","event_type":"KeyEvent"},{"event_id":1771,"event":"Decrease, Adenosine triphosphate pool","event_type":"KeyEvent"},{"event_id":55,"event":"Increase, Cell injury/death","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1521,"event":"Decrease, Growth","event_type":"AdverseOutcome"}],"relationships":[{"relation":4534,"upstream_event_id":1115,"upstream_event":"Increase, Reactive oxygen species","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "},{"relation":4535,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":1767,"downstream_event":"Increase, Protein oxidation"},{"relation":4536,"upstream_event_id":1767,"upstream_event":"Increase, Protein oxidation","downstream_event_id":179,"downstream_event":"Decrease, Fatty acid beta-oxidation"},{"relation":4537,"upstream_event_id":179,"upstream_event":"Decrease, Fatty acid beta-oxidation","downstream_event_id":1771,"downstream_event":"Decrease, Adenosine triphosphate pool"},{"relation":4538,"upstream_event_id":1771,"upstream_event":"Decrease, Adenosine triphosphate pool","downstream_event_id":55,"downstream_event":"Increase, Cell injury/death"},{"relation":4539,"upstream_event_id":55,"upstream_event":"Increase, Cell injury/death","downstream_event_id":1521,"downstream_event":"Decrease, Growth"}]}