{"id":642,"title":"Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation","short_name":"Intestinal FXR inhibition to steatohepatitis","created_at":"2026-04-21T22:49:31.000-04:00","updated_at":"2026-04-28T04:06:08.000-04:00","corresponding_author":{"id":585,"created_at":"2018-03-20T08:57:53.000-04:00","updated_at":"2026-04-27T00:34:44.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":2421,"event":" Inhibition, Intestinal FXR","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2422,"event":"Ileal FGF15/FGF19 secretion, decreased","event_type":"KeyEvent"},{"event_id":2424,"event":"Hepatic CYP7A1, increased","event_type":"KeyEvent"},{"event_id":2425,"event":"Intrahepatic bile acid burden, increased","event_type":"KeyEvent"},{"event_id":2426,"event":"Hepatic BSEP (ABCB11), decreased","event_type":"KeyEvent"},{"event_id":2427,"event":"Bile acid composition in bile and intestine, altered","event_type":"KeyEvent"},{"event_id":1931,"event":"Intestinal barrier, disruption","event_type":"KeyEvent"},{"event_id":2428,"event":"Gut derived PAMPs, increased","event_type":"KeyEvent"},{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"},{"event_id":902,"event":"Inflammation, Liver","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1489,"event":"Increase, Steatohepatitis","event_type":"AdverseOutcome"}],"relationships":[{"relation":4934,"upstream_event_id":2421,"upstream_event":" Inhibition, Intestinal FXR","downstream_event_id":2422,"downstream_event":"Ileal FGF15/FGF19 secretion, decreased"},{"relation":4951,"upstream_event_id":902,"upstream_event":"Inflammation, Liver","downstream_event_id":1931,"downstream_event":"Intestinal barrier, disruption"},{"relation":4943,"upstream_event_id":2422,"upstream_event":"Ileal FGF15/FGF19 secretion, decreased","downstream_event_id":2424,"downstream_event":"Hepatic CYP7A1, increased"},{"relation":4944,"upstream_event_id":2424,"upstream_event":"Hepatic CYP7A1, increased","downstream_event_id":2425,"downstream_event":"Intrahepatic bile acid burden, increased"},{"relation":4945,"upstream_event_id":2425,"upstream_event":"Intrahepatic bile acid burden, increased","downstream_event_id":2426,"downstream_event":"Hepatic BSEP (ABCB11), decreased"},{"relation":4946,"upstream_event_id":2426,"upstream_event":"Hepatic BSEP (ABCB11), decreased","downstream_event_id":2427,"downstream_event":"Bile acid composition in bile and intestine, altered"},{"relation":4947,"upstream_event_id":2427,"upstream_event":"Bile acid composition in bile and intestine, altered","downstream_event_id":1931,"downstream_event":"Intestinal barrier, disruption"},{"relation":4948,"upstream_event_id":1931,"upstream_event":"Intestinal barrier, disruption","downstream_event_id":2428,"downstream_event":"Gut derived PAMPs, increased"},{"relation":4949,"upstream_event_id":2428,"upstream_event":"Gut derived PAMPs, increased","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "},{"relation":4950,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":902,"downstream_event":"Inflammation, Liver"},{"relation":4952,"upstream_event_id":902,"upstream_event":"Inflammation, Liver","downstream_event_id":1489,"downstream_event":"Increase, Steatohepatitis"}]}