{"id":646,"title":"Binding and activation of AhR/PPARγ lead to lipid metabolism disorders","short_name":"Binding and activation of AhR/PPARγ lead to lipid metabolism disorders","created_at":"2026-07-09T08:38:27.000-04:00","updated_at":"2026-07-25T02:19:19.000-04:00","corresponding_author":{"id":21145,"created_at":"2026-07-07T03:02:23.000-04:00","updated_at":"2026-07-25T02:16:57.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":860,"stressor_name":"Naphthalene"},{"stressor_id":869,"stressor_name":"Acenaphthylene"},{"stressor_id":868,"stressor_name":"Acenaphthene"},{"stressor_id":870,"stressor_name":"Fluorene"},{"stressor_id":46,"stressor_name":"Phenanthrene"},{"stressor_id":861,"stressor_name":"Anthracene"},{"stressor_id":871,"stressor_name":"Fluoranthene"},{"stressor_id":862,"stressor_name":"Pyrene"},{"stressor_id":863,"stressor_name":"Benz(a)anthracene"},{"stressor_id":864,"stressor_name":"Chrysene"},{"stressor_id":859,"stressor_name":"Benzo(b)fluoranthene"},{"stressor_id":10,"stressor_name":"Benzo(k)fluoranthene"},{"stressor_id":538,"stressor_name":"Benzo(a)pyrene"},{"stressor_id":872,"stressor_name":"Indeno(1,2,3-cd)pyrene"},{"stressor_id":873,"stressor_name":"Dibenz(a,h)anthracene"},{"stressor_id":874,"stressor_name":"Benzo(g,h,i)perylene"}],"aop_mies":[{"event_id":2430,"event":"Aryl hydrocarbon receptor（AhR）activation","event_type":"MolecularInitiatingEvent"},{"event_id":1507,"event":"Activation of PPARγ","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":80,"event":"Up Regulation, CYP1A1","event_type":"KeyEvent"},{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"},{"event_id":902,"event":"Inflammation, Liver","event_type":"KeyEvent"},{"event_id":2441,"event":"Increased , Fatty acid synthesis and transport","event_type":"KeyEvent"},{"event_id":1824,"event":"Decrease, Fatty acid β-oxidation","event_type":"KeyEvent"},{"event_id":2446,"event":"Increase, lipid accumulation","event_type":"KeyEvent"},{"event_id":786,"event":"Increase, Cytotoxicity (hepatocytes)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1995,"event":"Abnormal lipid metabolism","event_type":"AdverseOutcome"}],"relationships":[{"relation":5019,"upstream_event_id":2430,"upstream_event":"Aryl hydrocarbon receptor（AhR）activation","downstream_event_id":80,"downstream_event":"Up Regulation, CYP1A1"},{"relation":5021,"upstream_event_id":80,"upstream_event":"Up Regulation, CYP1A1","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "},{"relation":5033,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":902,"downstream_event":"Inflammation, Liver"},{"relation":5025,"upstream_event_id":2430,"upstream_event":"Aryl hydrocarbon receptor（AhR）activation","downstream_event_id":1507,"downstream_event":"Activation of PPARγ"},{"relation":5020,"upstream_event_id":1507,"upstream_event":"Activation of PPARγ","downstream_event_id":2441,"downstream_event":"Increased , Fatty acid synthesis and transport"},{"relation":5022,"upstream_event_id":1507,"upstream_event":"Activation of PPARγ","downstream_event_id":1824,"downstream_event":"Decrease, Fatty acid β-oxidation"},{"relation":5034,"upstream_event_id":2441,"upstream_event":"Increased , Fatty acid synthesis and transport","downstream_event_id":2446,"downstream_event":"Increase, lipid accumulation"},{"relation":5035,"upstream_event_id":1824,"upstream_event":"Decrease, Fatty acid β-oxidation","downstream_event_id":2446,"downstream_event":"Increase, lipid accumulation"},{"relation":5036,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":786,"downstream_event":"Increase, Cytotoxicity (hepatocytes)"},{"relation":5037,"upstream_event_id":2446,"upstream_event":"Increase, lipid accumulation","downstream_event_id":786,"downstream_event":"Increase, Cytotoxicity (hepatocytes)"},{"relation":5038,"upstream_event_id":786,"upstream_event":"Increase, Cytotoxicity (hepatocytes)","downstream_event_id":1995,"downstream_event":"Abnormal lipid metabolism"}]}