{"id":7,"title":"Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female","short_name":"Aromatase (Cyp19a1) reduction leading to reproductive toxicity","created_at":"2016-11-29T18:41:15.000-05:00","updated_at":"2023-04-29T16:02:54.000-04:00","corresponding_author":{"id":109,"created_at":"2016-07-01T09:27:11.000-04:00","updated_at":"2021-04-13T09:40:27.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":408,"event":"reduction in ovarian granulosa cells, Aromatase (Cyp19a1)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":219,"event":"Reduction, Plasma 17beta-estradiol concentrations","event_type":"KeyEvent"},{"event_id":3,"event":"Reduction, 17beta-estradiol synthesis by ovarian granulosa cells","event_type":"KeyEvent"}],"aop_aos":[{"event_id":406,"event":"decreased, Fertility","event_type":"AdverseOutcome"},{"event_id":405,"event":"disrupted, ovarian cycle","event_type":"AdverseOutcome"}],"relationships":[{"relation":126,"upstream_event_id":219,"upstream_event":"Reduction, Plasma 17beta-estradiol concentrations","downstream_event_id":405,"downstream_event":"disrupted, ovarian cycle"},{"relation":127,"upstream_event_id":3,"upstream_event":"Reduction, 17beta-estradiol synthesis by ovarian granulosa cells","downstream_event_id":219,"downstream_event":"Reduction, Plasma 17beta-estradiol concentrations"},{"relation":128,"upstream_event_id":405,"upstream_event":"disrupted, ovarian cycle","downstream_event_id":406,"downstream_event":"decreased, Fertility"},{"relation":637,"upstream_event_id":408,"upstream_event":"reduction in ovarian granulosa cells, Aromatase (Cyp19a1)","downstream_event_id":3,"downstream_event":"Reduction, 17beta-estradiol synthesis by ovarian granulosa cells"}]}