{"id":72,"title":"Epigenetic modification of PPARG leading to adipogenesis","short_name":"PPARG mod to adipogenesis","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2026-01-11T16:56:06.000-05:00","corresponding_author":{"id":28,"created_at":"2014-10-23T10:16:40.000-04:00","updated_at":"2024-11-26T10:11:20.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":304,"stressor_name":"Tributyltin"}],"aop_mies":[{"event_id":228,"event":"peroxisome proliferator activated receptor promoter demethylation","event_type":"MolecularInitiatingEvent"},{"event_id":1454,"event":"chronic high fat diet","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1028,"event":"Activation of specific nuclear receptors, PPAR-gamma activation","event_type":"KeyEvent"},{"event_id":1448,"event":"activation of CCAAT/enhancer-binding protein alpha","event_type":"KeyEvent"},{"event_id":1449,"event":"increased adipogenesis","event_type":"KeyEvent"},{"event_id":1450,"event":"decreased dopamine","event_type":"KeyEvent"},{"event_id":1451,"event":"decreased reward","event_type":"KeyEvent"},{"event_id":1452,"event":"decreased DNA methylation of tyrosine hydroxylase","event_type":"KeyEvent"},{"event_id":1453,"event":"decreased methylation of dopamine transporter promoter","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1447,"event":"obesity","event_type":"AdverseOutcome"}],"relationships":[{"relation":1472,"upstream_event_id":228,"upstream_event":"peroxisome proliferator activated receptor promoter demethylation","downstream_event_id":1028,"downstream_event":"Activation of specific nuclear receptors, PPAR-gamma activation"},{"relation":1473,"upstream_event_id":1028,"upstream_event":"Activation of specific nuclear receptors, PPAR-gamma activation","downstream_event_id":1449,"downstream_event":"increased adipogenesis"},{"relation":1474,"upstream_event_id":1448,"upstream_event":"activation of CCAAT/enhancer-binding protein alpha","downstream_event_id":1028,"downstream_event":"Activation of specific nuclear receptors, PPAR-gamma activation"},{"relation":1475,"upstream_event_id":1448,"upstream_event":"activation of CCAAT/enhancer-binding protein alpha","downstream_event_id":1449,"downstream_event":"increased adipogenesis"},{"relation":1476,"upstream_event_id":1449,"upstream_event":"increased adipogenesis","downstream_event_id":1447,"downstream_event":"obesity"},{"relation":1477,"upstream_event_id":1454,"upstream_event":"chronic high fat diet","downstream_event_id":1450,"downstream_event":"decreased dopamine"},{"relation":1478,"upstream_event_id":1450,"upstream_event":"decreased dopamine","downstream_event_id":1451,"downstream_event":"decreased reward"},{"relation":1479,"upstream_event_id":1451,"upstream_event":"decreased reward","downstream_event_id":1452,"downstream_event":"decreased DNA methylation of tyrosine hydroxylase"},{"relation":1480,"upstream_event_id":1451,"upstream_event":"decreased reward","downstream_event_id":1453,"downstream_event":"decreased methylation of dopamine transporter promoter"},{"relation":1481,"upstream_event_id":1451,"upstream_event":"decreased reward","downstream_event_id":1450,"downstream_event":"decreased dopamine"},{"relation":1482,"upstream_event_id":1452,"upstream_event":"decreased DNA methylation of tyrosine hydroxylase","downstream_event_id":1447,"downstream_event":"obesity"},{"relation":1483,"upstream_event_id":1453,"upstream_event":"decreased methylation of dopamine transporter promoter","downstream_event_id":1447,"downstream_event":"obesity"},{"relation":1484,"upstream_event_id":1452,"upstream_event":"decreased DNA methylation of tyrosine hydroxylase","downstream_event_id":1450,"downstream_event":"decreased dopamine"},{"relation":1485,"upstream_event_id":1453,"upstream_event":"decreased methylation of dopamine transporter promoter","downstream_event_id":1450,"downstream_event":"decreased dopamine"}]}