SNAPSHOT
Created at: 2019-01-04 08:58
AOP ID and Title:
AOP 71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
Short Title: Decreased Adult Testosterone 2
Status
| Author status | OECD status | OECD project | SAAOP status |
|---|---|---|---|
| Under development: Not open for comment. Do not cite | 1.29 | Under Development |
Summary of the AOP
Events
Molecular Initiating Events (MIE), Key Events (KE), Adverse Outcomes (AO)
| Sequence | Type | Event ID | Title | Short name |
|---|---|---|---|---|
| 1 | MIE | 650 | Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid | Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid |
| 2 | KE | 525 | Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells | Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells |
| 3 | KE | 651 | Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells | Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testostero |
| 4 | KE | 652 | Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells | Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig |
| 5 | AO | 520 | Decreased sperm quantity or quality in the adult, Decreased fertility | Decreased sperm quantity or quality in the adult, Decreased fertility |
Key Event Relationships
There are no Relationships associated with this AOPOverall Assessment of the AOP
Domain of Applicability
Life Stage Applicability| Life Stage | Evidence |
|---|---|
| Adult, reproductively mature | High |
| Term | Scientific Term | Evidence | Links |
|---|---|---|---|
| Rattus norvegicus | Rattus norvegicus | High | NCBI |
| Homo sapiens | Homo sapiens | High | NCBI |
| Sex | Evidence |
|---|---|
| Male | High |
References
Appendix 1
List of MIEs in this AOP
Event: 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
Short Name: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
Key Event Component
| Process | Object | Action |
|---|---|---|
| glucocorticoid biosynthetic process | glucocorticoid | increased |
| cell activation | increased |
AOPs Including This Key Event
| AOP ID and Name | Event Type |
|---|---|
| Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation | MolecularInitiatingEvent |
Biological Context
| Level of Biological Organization |
|---|
| Molecular |
List of Key Events in the AOP
Event: 525: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
Short Name: Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
Key Event Component
| Process | Object | Action |
|---|---|---|
| testosterone | decreased | |
| apoptotic process | increased |
AOPs Including This Key Event
| AOP ID and Name | Event Type |
|---|---|
| Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation | KeyEvent |
Biological Context
| Level of Biological Organization |
|---|
| Cellular |
Cell term
| Cell term |
|---|
| Leydig cell |
Event: 651: Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells
Short Name: Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testostero
Key Event Component
| Process | Object | Action |
|---|---|---|
| glucocorticoid receptor activity | glucocorticoid receptor | abnormal |
AOPs Including This Key Event
| AOP ID and Name | Event Type |
|---|---|
| Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation | KeyEvent |
Biological Context
| Level of Biological Organization |
|---|
| Cellular |
Event: 652: Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
Short Name: Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig
Key Event Component
| Process | Object | Action |
|---|---|---|
| regulation of steroid biosynthetic process | abnormal |
AOPs Including This Key Event
| AOP ID and Name | Event Type |
|---|---|
| Aop:71 - Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation | KeyEvent |
Biological Context
| Level of Biological Organization |
|---|
| Cellular |
List of Adverse Outcomes in this AOP
Event: 520: Decreased sperm quantity or quality in the adult, Decreased fertility
Short Name: Decreased sperm quantity or quality in the adult, Decreased fertility
Key Event Component
| Process | Object | Action |
|---|---|---|
| sperm quantity | decreased | |
| sperm | morphological change | |
| fertility | decreased | |
| sperm | decreased |
AOPs Including This Key Event
Biological Context
| Level of Biological Organization |
|---|
| Individual |