[{"id":26,"title":"My DART AOPs","purpose":"A collection of AOPs considered related to Developmental and Reproductive Toxicity","creation_strategy":"A list of candidate DART-related AOPs, identified with the help of AI, as presented in the 24 September 2026 ISTNET-DART meeting in Basel, Switzerland","collection_type":"aop","status":"submitted","creator_id":72,"item_count":11,"submitted_at":"2026-10-13T05:30:54.000-04:00","approved_at":null},{"id":20,"title":"Inflammation-Related Key Events","purpose":"Key Events related to different types of inflammation across diverse Adverse Outcome Pathways following exposure to different chemical, physical, or biological stressors.","creation_strategy":null,"collection_type":"event","status":"draft","creator_id":21063,"item_count":17,"submitted_at":null,"approved_at":null},{"id":19,"title":"Adverse Outcome Pathways with Reactive Oxygen Species as a MIE","purpose":"AOPs in which increased reactive oxygen species (ROS) serves as a molecular initiating event (MIE), leading to diverse adverse outcomes following exposure to different chemical, physical, or biological stressors.","creation_strategy":"Manual inspection of AOPs containing increased reactive oxygen species (ROS) as at least one MIE. Search term in the MIE column: *reactive oxygen species\r\n","collection_type":"aop","status":"draft","creator_id":21063,"item_count":31,"submitted_at":null,"approved_at":null},{"id":18,"title":"Lung cancer AOPs","purpose":"AOPs related to lung cancer development or progression caused by chemical, physical, or biological stressors.","creation_strategy":"Manual inspection of AOs and AOP titles for: *Lung cancer *Lung carcinoma *Lung neoplasms *Small cell lung cancer *Non-small cell lung cancer *Pulmonary tumorigenesis *Lung tumor development *Lung cancer progression *Malignant transformation of lung cells","collection_type":"aop","status":"submitted","creator_id":21063,"item_count":6,"submitted_at":"2026-08-27T12:49:49.000-04:00","approved_at":null},{"id":17,"title":"Network of Reactive Oxygen Species (ROS)","purpose":"AOPs linked with ROS-related KEs discussed at the Mystery of ROS consortium are collected. \r\nRef. 1: Tanabe S, Beaton D, Chauhan V, Choi I, Danielsen PH, Delrue N, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Gant TW, Garcia-Reyero N, Helm JS, Huliganga E, Jacobsen NR, Kay JE, Kim YJ, Klose J, La Rocca C, Luettich K, Mally A, O'Brien J, Poulsen SS, Rudel RA, Sovadinova I, Tollefsen KE, Vogel U, Yepiskoposyan H, Yauk C. Report of the 1st and 2nd Mystery of Reactive Oxygen Species Conferences. ALTEX. 2022;39(2):336-338. doi: 10.14573/altex.2203011. PMID: 37470453.\r\nRef. 2: Tanabe S, O'Brien J, Tollefsen KE, Kim Y, Chauhan V, Yauk C, Huliganga E, Rudel RA, Kay JE, Helm JS, Beaton D, Filipovska J, Sovadinova I, Garcia-Reyero N, Mally A, Poulsen SS, Delrue N, Fritsche E, Luettich K, La Rocca C, Yepiskoposyan H, Klose J, Danielsen PH, Esterhuizen M, Jacobsen NR, Vogel U, Gant TW, Choi I, FitzGerald R. Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events. Front Toxicol. 2022 Jul 6;4:887135. doi: 10.3389/ftox.2022.887135. PMID: 35875696; PMCID: PMC9298159.\r\nRef. 3: Tanabe S, Beaton D, Chauhan V, Choi I, Choi J, Clerbaux LA, Coppola L, Dumont AF, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Garcia-Reyero N, Goralczyk A, Huliganga E, Kim YJ, Klose J, La Rocca C, Landesmann B, Mally A, Murugadoss S, Omeragic E, Ouédraogo G, Pereira JM, Sadi B, Schaffert A, Song Y, Sovadinova I, Stöger T, Tollefsen KE, Wittwehr C, Yauk C. Report of the 3rd and 4th Mystery of Reactive Oxygen Species Conference. ALTEX. 2023;40(4):689-693. doi: 10.14573/altex.2307041. PMID: 37889188.\r\nRef. 4: Tanabe S, Beaton D, Becker RA, Chauhan V, Choi J, Choi E, Cole A, Cooke MS, Coppola L, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Gant TW, Gayen K, Hajizadeh N, Hamada N, Hench VK, Huzain O, Karschnik T, Katsiadaki I, Kim YJ, La Rocca C, Mally A, Omeragic E, Ouédraogo G, Reyero N, Schaffert A, Song Y, Sovadinova I, Tao R, Tsukano M, Villeneuve D, Vogel U, Yauk CL. Report on the 5th and 6th Mystery of Reactive Oxygen Species Conferences. ALTEX. 2026;43(2):353-358. doi: 10.14573/altex.2512041. PMID: 41982194.","creation_strategy":"AOPs are listed based on Figure 1 in Reference 1 (Report of the 1st and 2nd Mystery of Reactive Oxygen Species Conferences. ALTEX. 2022;39(2):336-338. doi: 10.14573/altex.2203011.)","collection_type":"aop","status":"submitted","creator_id":355,"item_count":15,"submitted_at":"2026-08-19T21:17:01.000-04:00","approved_at":null},{"id":16,"title":"EDSP","purpose":"A collection of AOPs linking endocrine MIEs or early KEs to endpoints measured in guideline studies relevant to the U.S. Endocrine Disruptor Screening Program.","creation_strategy":null,"collection_type":"aop","status":"draft","creator_id":313,"item_count":24,"submitted_at":null,"approved_at":null},{"id":15,"title":"Immunotoxicity AOPs","purpose":"AOPs related to an adverse alteration of immune system function or integrity caused by a stressor, resulting in impaired immune defense, inappropriate immune activation, hypersensitivity, autoimmunity, or disrupted immune development.","creation_strategy":"Manual inspection of AOs and AOP titles for:\r\n* Immunosuppression\r\n* Immune hyperactivation\r\n* Increased disease susceptibility\r\n* Hypersensitivity\r\n* Autoimmunity\r\n* Developmental immunotoxicity","collection_type":"aop","status":"submitted","creator_id":13469,"item_count":20,"submitted_at":"2026-08-10T13:45:41.000-04:00","approved_at":null},{"id":14,"title":"Cell death","purpose":"testing","creation_strategy":null,"collection_type":"event","status":"draft","creator_id":1120,"item_count":0,"submitted_at":null,"approved_at":null},{"id":13,"title":"AOP Network linking nAChR activation to colony death/failure in social bees","purpose":"Taxonomic domain of applicability of this network for other Apis and non-Apis bee species was examined by Jensen et al. 2022.  https://doi.org/10.1002/etc.5501","creation_strategy":"This group of AOPs was developed by Carlie Lalone (2017; doi: 10.1016/j.scitotenv.2017.01.113.) and was the focus of a tDOA case study in 2023 (Jensen et al. https://doi.org/10.1002/etc.5501)","collection_type":"aop","status":"approved","creator_id":313,"item_count":6,"submitted_at":"2026-07-05T10:00:13.000-04:00","approved_at":"2026-08-19T07:51:17.000-04:00"}]