AOP-Wiki

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All Key Events

Showing 1826 to 1850 of 1947 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

980	Inhibition, Calcineurin Activity Short Name Inhibition, Calcineurin Activity	2	Molecular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
973	KE5 : Decrease, AKT/eNOS activity Short Name Decrease, AKT/eNOS activity	2	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
962	Increase, Mucin production Short Name Increase, Mucin production	2	Cellular	Nov 29, 2016	Mar 9, 2023	148: EGFR Activation Leading to Decreased Lung Function
1000	stabilization, PPAR alpha co-repressor Short Name stabilization, PPAR alpha co-repressor	2	Molecular	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
927	KE1 : S-Glutathionylation, eNOS Short Name S-Glutathionylation, eNOS	2	Molecular	Nov 29, 2016	Nov 20, 2017	149: Peptide Oxidation Leading to Hypertension
941	Activation, EGFR Short Name Activation, EGFR	2	Molecular	Nov 29, 2016	Mar 8, 2023	148: EGFR Activation Leading to Decreased Lung Function
944	dimerization, AHR/ARNT Short Name dimerization, AHR/ARNT	2	Molecular	Nov 29, 2016	May 31, 2025	7 AOPs 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 151: AhR activation leading to preeclampsia 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
870	Increase, Cell Proliferation Short Name Increase, Cell Proliferation	2	Cellular	Nov 29, 2016	Dec 10, 2024	9 AOPs 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors 303: Frustrated phagocytosis-induced lung cancer 272: Deposition of energy leading to lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 451: Interaction with lung resident cell membrane components leads to lung cancer 478: Deposition of energy leading to occurrence of cataracts 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
868	Increase, Tissue Degeneration, Necrosis & Atrophy Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
862	Not Increased, Circulating Ketone Bodies Short Name	2	Tissue	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
856	Formation, Hepatocellular and Bile duct tumors Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	41: Sustained AhR Activation leading to Rodent Liver Tumours
565	Reduced, Brood care Short Name Reduced, Brood care	2	Population	Nov 29, 2016	Dec 3, 2016	3 AOPs 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
573	Increase, Energetic demands and therefore metabolic stress Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
584	Inhibition, sodium channel Short Name Inhibition, sodium channel	2	Molecular	Nov 29, 2016	Sep 16, 2017	5 AOPs 91: Sodium channel inhibition leading to reduced survival 93: sodium channel inhibition leading to increased predation 94: Sodium channel inhibition leading to congenital malformations 197: Sodium channel (Nav1.1) inhibition leading to population decline 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
619	Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Short Name	2	Molecular	Nov 29, 2016	Feb 24, 2025	6 AOPs 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
650	Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid Short Name	2	Molecular	Nov 29, 2016	Dec 3, 2016	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
657	Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Dec 3, 2016	2 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
660	decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
663	Desensitization, Nicotinic acetylcholine receptor Short Name	2	Molecular	Nov 29, 2016	Jun 7, 2018	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
675	Reduced, Reproductive Success Short Name Reduced, Reproductive Success	2	Individual	Nov 29, 2016	Dec 3, 2016	5 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 63: Cyclooxygenase inhibition leading to reproductive dysfunction 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
692	Reduced, Maturation inducing steroid receptor signalling, oocyte Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
697	impaired, ion channels Short Name impaired, ion channels	2	Cellular	Nov 29, 2016	Dec 3, 2016	104: Altered ion channel activity leading impaired heart function
716	Increase, cell proliferation (hepatocytes) Short Name	2	Cellular	Nov 29, 2016	Jan 6, 2021	3 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
718	Binding, Tubulin Short Name Binding, Tubulin	2	Molecular	Nov 29, 2016	Apr 20, 2021	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
736	Increase, Adenomas/carcinomas (bronchioloalveolar) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)