AOP-Wiki

API

All Key Events

Showing 1 to 25 of 1911 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2403	Metabolic impairment Short Name Metabolic impairment	0	Cellular	Feb 6, 2026	Feb 6, 2026	622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
2365	Anogenital distance (AGD), increased Short Name AGD, increased	0	Tissue	Sep 5, 2025	Dec 8, 2025	547: Androgen receptor agonism leading to long anogenital distance in female offspring
2387	MIE-A: Direct ligand interaction with nuclear hormone receptors (ERα/ERβ, AR) or interference with steroidogenic enzymes (e.g., CYP19A1) → receptor activation/antagonism or enzyme inhibition. Short Name	0	Molecular	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways
2388	MIE-B: Photoactivation / photoproduct formation leading to ROS generation Short Name photoproducts generate ROS	0	Molecular	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways
2389	KE1: Altered steroidogenesis (gene/protein level) Short Name Altered steroidogenesis	0	Cellular	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways
2362	Redox cycling of a chemical by mitochondria Short Name Redox cycling	0	Molecular	Sep 5, 2025	Oct 3, 2025	593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
2391	Reduced fertility / fecundity Short Name Reduced fertility	0	Individual	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways
2392	Depression Short Name Depression	0	Individual	Nov 9, 2025	Nov 10, 2025	None
2394	Diminished survival of naive B lymphocytes Short Name Lower survival B lymphocytes	0	Cellular	Dec 3, 2025	Dec 3, 2025	618: PPARgamma activation leads to a diminished vaccine response
2395	Diminished proliferation of activated B lymphocytes Short Name	0	Cellular	Dec 3, 2025	Dec 3, 2025	618: PPARgamma activation leads to a diminished vaccine response
2396	Diminished differentiation of activated B lymphocytes Short Name	0	Cellular	Dec 3, 2025	Dec 3, 2025	618: PPARgamma activation leads to a diminished vaccine response
2397	Diminished vaccine response Short Name Diminished vaccine response	0	Individual	Dec 3, 2025	Dec 3, 2025	618: PPARgamma activation leads to a diminished vaccine response
2398	Reduced antibody production Short Name Reduced antibody production	0	Cellular	Dec 3, 2025	Dec 3, 2025	618: PPARgamma activation leads to a diminished vaccine response
2390	KE5: Altered circulating reproductive hormones Short Name reproductive hormonal Imbalance	0	Organ	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways
2404	Increase, kidney fibrosis Short Name Increase, kidney fibrosis	0	Tissue	Feb 6, 2026	Feb 27, 2026	622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
2405	Increase, Hepatocellular lipotoxicity Short Name Increase, Hepatocellular lipotoxicity	0	Cellular	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
2406	Increase, Regenerative nodule formation Short Name Increase, Regenerative nodule formation	0	Tissue	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
2407	Increase, Cirrhosis Short Name Increase, Cirrhosis	0	Organ	Feb 10, 2026	Feb 11, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
2408	Increase, Adipose lipolysis Short Name Increase, Adipose lipolysis	0	Tissue	Feb 10, 2026	Feb 10, 2026	3 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
2409	Decrease, 11β-Hydroxysteroid dehydrogenase type 2 activity Short Name Decrease, 11β-HSD2 activity	0	Molecular	Feb 10, 2026	Feb 26, 2026	630: Decreased 11β-Hydroxysteroid dehydrogenase type 2 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction
2410	Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Short Name Increase, 11β-HSD1 activity	0	Molecular	Feb 18, 2026	Feb 18, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
2411	Increase, Circulating active glucocorticoid availability Short Name	0	Organ	Feb 18, 2026	Feb 24, 2026	None
2412	Increase, Hepatic intracellular active glucocorticoids Short Name	0	Cellular	Feb 18, 2026	Feb 26, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
2414	COL3A1 Signaling Pathway Short Name COL3A1 Signaling Pathway	0	Molecular	Mar 25, 2026	Mar 25, 2026	638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
2416	human amyotrophic lateral sclerosis (ALS) Short Name ALS	0	Individual	Mar 30, 2026	Mar 30, 2026	636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)