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All KERs

Showing 1 to 25 of 3110 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

368	352: N/A, Neurodegeneration	386: Neuronal network function, Decreased	Nov 29, 2016	Dec 3, 2016	None
390	168: Decreased, Lymphocytes	403: Suppression, Immune system	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
389	168: Decreased, Lymphocytes	323: Increased, Disease susceptibility	Nov 29, 2016	Dec 3, 2016	None
388	152: Suppression, Inflammatory cytokines	168: Decreased, Lymphocytes	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
387	202: Inhibition, Nuclear factor kappa B (NF-kB)	152: Suppression, Inflammatory cytokines	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
386	145: Induction, IKB inhibitory protein	202: Inhibition, Nuclear factor kappa B (NF-kB)	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
385	122: Increase, GR activation	145: Induction, IKB inhibitory protein	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
384	192: Altered, Neurophysiology	402: Cognitive function, decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
383	279: Thyroperoxidase, Inhibition	402: Cognitive function, decreased	Nov 29, 2016	Dec 3, 2016	None
380	397: Response, Keratinocytes	272: Activation/Proliferation, T-cells	Nov 29, 2016	Dec 3, 2016	None
379	398: Activation, Dendritic Cells	272: Activation/Proliferation, T-cells	Nov 29, 2016	Aug 22, 2022	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
378	397: Response, Keratinocytes	398: Activation, Dendritic Cells	Nov 29, 2016	Nov 29, 2016	None
377	396: Covalent Binding, Protein	398: Activation, Dendritic Cells	Nov 29, 2016	Nov 5, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
376	396: Covalent Binding, Protein	397: Response, Keratinocytes	Nov 29, 2016	Dec 3, 2016	None
370	227: Activation, PPARα	289: Decrease, Translocator protein (TSPO)	Nov 29, 2016	Dec 2, 2016	1 AOP 18: PPARα activation in utero leading to impaired fertility in males
369	227: Activation, PPARα	266: Decrease, Steroidogenic acute regulatory protein (STAR)	Nov 29, 2016	Dec 2, 2016	1 AOP 18: PPARα activation in utero leading to impaired fertility in males
366	279: Thyroperoxidase, Inhibition	281: T4 in serum, Decreased	Nov 29, 2016	Nov 18, 2025	4 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
348	381: BDNF, Reduced	382: Aberrant, Dendritic morphology	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
358	385: Synaptogenesis, Decreased	386: Neuronal network function, Decreased	Nov 29, 2016	May 25, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
357	383: Reduced, Presynaptic release of glutamate	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
356	382: Aberrant, Dendritic morphology	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
355	55: Cell injury/death	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
354	381: BDNF, Reduced	383: Reduced, Presynaptic release of glutamate	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
353	381: BDNF, Reduced	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	2 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
352	373: Formation, Pro-mutagenic DNA Adducts	384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci	Nov 29, 2016	Nov 29, 2016	None

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