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All KERs

Showing 1 to 25 of 3110 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

5	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	219: Reduction, Plasma 17beta-estradiol concentrations	Nov 29, 2016	Mar 20, 2017	6 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
9	8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity	179: Decrease, Fatty acid β-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
11	12: AchE Inhibition	10: ACh Synaptic Accumulation	Nov 29, 2016	Sep 10, 2023	4 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
16	17: Altered expression of AHR/ARNT pathway-dependent genes	317: Altered, Cardiovascular development/function	Nov 29, 2016	Dec 3, 2016	None
17	17: Altered expression of AHR/ARNT pathway-dependent genes	80: Up Regulation, CYP1A1	Nov 29, 2016	Dec 3, 2016	None
18	18: Activation, AhR	17: Altered expression of AHR/ARNT pathway-dependent genes	Nov 29, 2016	Dec 3, 2016	None
19	18: Activation, AhR	80: Up Regulation, CYP1A1	Nov 29, 2016	Dec 3, 2016	1 AOP 57: AhR activation leading to hepatic steatosis
23	97: Alkylation, DNA	336: Increase, Heritable mutations in offspring	Nov 29, 2016	Nov 29, 2016	1 AOP 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
24	97: Alkylation, DNA	155: Inadequate DNA repair	Nov 29, 2016	Dec 10, 2019	3 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1 322: Alkylation of DNA leading to reduced sperm count
25	97: Alkylation, DNA	185: Increase, Mutations	Nov 29, 2016	Nov 29, 2016	2 AOPs 15: Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations 139: Alkylation of DNA leading to cancer 1
31	25: Agonism, Androgen receptor	129: Reduction, Gonadotropins, circulating concentrations	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
32	25: Agonism, Androgen receptor	274: Reduction, Testosterone synthesis by ovarian theca cells	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
36	28: Reduction, Angiogenesis	110: Impairment, Endothelial network	Nov 29, 2016	Jan 18, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
45	36: Inhibition, Aromatase	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Nov 30, 2016	1 AOP 25: Aromatase inhibition leading to reproductive dysfunction
51	39: Increased Cholinergic Signaling	360: Decrease, Population growth rate	Nov 29, 2016	Dec 3, 2016	None
59	49: Reduction, Ca and HCO3 transport to shell gland	106: Reduction, Eggshell thickness	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
60	50: Increase, Ca++ (intracellular)	178: Mitochondrial electron transport chain, disrupted	Nov 29, 2016	Dec 3, 2016	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
61	51: Inhibition, Ca++ ATPase	50: Increase, Ca++ (intracellular)	Nov 29, 2016	Dec 3, 2016	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
62	52: Decreased, Calcium influx	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	None
66	54: Up Regulation, CD36	115: Increase, FA influx	Nov 29, 2016	Mar 27, 2024	2 AOPs 34: LXR activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis
67	55: Cell injury/death	134: Increase, Kupffer cell activation	Nov 29, 2016	Nov 29, 2016	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
68	55: Cell injury/death	265: Increase, HSC activation	Nov 29, 2016	Apr 21, 2026	2 AOPs 38: Protein Alkylation leading to Liver Fibrosis 494: AhR activation leading to liver fibrosis
69	57: Proliferation, Cell proliferation in the absence of cytotoxicity	142: Hyperplasia, Hyperplasia	Nov 29, 2016	Dec 3, 2016	1 AOP 1: Uncharacterized liver damage leading to hepatocellular carcinoma
70	60: Induction, Chitin degradation and resorption	238: Induction, Pre-mature molting	Nov 29, 2016	Dec 3, 2016	None
77	66: Activation, ChREBP	89: Synthesis, De Novo Fatty Acid (FA)	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis

Key Event Relationships (KERs)

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