Key Event Relationships (KERs)

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Showing 1 to 25 of 3110 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
23 97: Alkylation, DNA 336: Increase, Heritable mutations in offspring Nov 29, 2016 Nov 29, 2016
25 97: Alkylation, DNA 185: Increase, Mutations Nov 29, 2016 Nov 29, 2016
67 55: Cell injury/death 134: Increase, Kupffer cell activation Nov 29, 2016 Nov 29, 2016
147 134: Increase, Kupffer cell activation 276: Up Regulation, TGFbeta1 expression Nov 29, 2016 Nov 29, 2016 None
172 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Nov 29, 2016 Nov 29, 2016
202 185: Increase, Mutations 336: Increase, Heritable mutations in offspring Nov 29, 2016 Nov 29, 2016
203 186: Altered, Neuroanatomy 192: Altered, Neurophysiology Nov 29, 2016 Nov 29, 2016
210 191: Neuronal dysfunction 188: Neuroinflammation Nov 29, 2016 Nov 29, 2016 None
253 219: Reduction, Plasma 17beta-estradiol concentrations 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Nov 29, 2016 Nov 29, 2016 None
269 244: Alkylation, Protein 55: Cell injury/death Nov 29, 2016 Nov 29, 2016
304 276: Up Regulation, TGFbeta1 expression 265: Increase, HSC activation Nov 29, 2016 Nov 29, 2016 None
342 376: Increased, Induced Mutations in Critical Genes 377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H Nov 29, 2016 Nov 29, 2016 None
343 377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H 378: Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 29, 2016 None
345 373: Formation, Pro-mutagenic DNA Adducts 378: Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 29, 2016
348 381: BDNF, Reduced 382: Aberrant, Dendritic morphology Nov 29, 2016 Nov 29, 2016
351 376: Increased, Induced Mutations in Critical Genes 384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Nov 29, 2016 Nov 29, 2016 None
352 373: Formation, Pro-mutagenic DNA Adducts 384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Nov 29, 2016 Nov 29, 2016 None
353 381: BDNF, Reduced 55: Cell injury/death Nov 29, 2016 Nov 29, 2016
354 381: BDNF, Reduced 383: Reduced, Presynaptic release of glutamate Nov 29, 2016 Nov 29, 2016
355 55: Cell injury/death 385: Synaptogenesis, Decreased Nov 29, 2016 Nov 29, 2016
356 382: Aberrant, Dendritic morphology 385: Synaptogenesis, Decreased Nov 29, 2016 Nov 29, 2016
357 383: Reduced, Presynaptic release of glutamate 385: Synaptogenesis, Decreased Nov 29, 2016 Nov 29, 2016
360 387: Binding of agonist, NMDARs 388: Overactivation, NMDARs Nov 29, 2016 Nov 29, 2016 None
362 389: Increased, Intracellular Calcium overload 177: Increase, Mitochondrial dysfunction Nov 29, 2016 Nov 29, 2016
363 177: Increase, Mitochondrial dysfunction 55: Cell injury/death Nov 29, 2016 Nov 29, 2016