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All KERs

Showing 2926 to 2950 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3591	2347: Increase, Lipid degradation	459: Increase, Liver steatosis	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
3592	459: Increase, Liver steatosis	2019: Non-alcoholic fatty liver disease	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
3593	1635: Increase, DNA strand breaks	1281: Increased, DNA Damage-Repair	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3594	1281: Increased, DNA Damage-Repair	2354: Activation, Apoptosis signaling	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3595	2349: Inhibition of LDH activity	2350: Decreased, Glycolysis	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3596	2350: Decreased, Glycolysis	2351: Increased, OXPHOS	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3597	2351: Increased, OXPHOS	2352: Increased, MMP	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3598	2352: Increased, MMP	2353: Disrupted, energy metabolism	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3599	2353: Disrupted, energy metabolism	2354: Activation, Apoptosis signaling	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3600	2354: Activation, Apoptosis signaling	2355: Disrupted, Spermatogenesis and Sperm quality	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3601	2355: Disrupted, Spermatogenesis and Sperm quality	406: decreased, Fertility	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
3602	1392: Increase, Oxidative Stress	1446: Decrease, Coupling of OXPHOS	Aug 21, 2025	Aug 21, 2025	None
3603	1771: Decrease, ATP pool	2327: Decrease, Cell growth	Aug 21, 2025	Aug 21, 2025	1 AOP 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth
3604	2327: Decrease, Cell growth	1521: Decrease, Growth	Aug 21, 2025	Aug 21, 2025	1 AOP 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth
3605	1066: Promotion, SIX1 positive progenitor cells in endometrium	1560: Cell differentiation, altered	Aug 21, 2025	Aug 28, 2025	None
3606	1560: Cell differentiation, altered	1068: Endometrial squamous metaplasia, Increase	Aug 21, 2025	Aug 28, 2025	None
3607	1068: Endometrial squamous metaplasia, Increase	772: Increase, Hyperplasia (glandular epithelial cells of endometrium)	Aug 26, 2025	Aug 26, 2025	None
3608	772: Increase, Hyperplasia (glandular epithelial cells of endometrium)	1070: Increased, adenosquamous carcinomas of endometrium	Aug 26, 2025	Sep 18, 2025	1 AOP 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
3609	1560: Cell differentiation, altered	772: Increase, Hyperplasia (glandular epithelial cells of endometrium)	Aug 26, 2025	Aug 29, 2025	None
3610	1068: Endometrial squamous metaplasia, Increase	1070: Increased, adenosquamous carcinomas of endometrium	Aug 26, 2025	Sep 18, 2025	1 AOP 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
3611	1115: Increase, ROS	1862: Decrease, Photosystem II efficiency	Sep 2, 2025	Sep 2, 2025	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
3612	1475: Decrease, Photosynthesis	360: Decrease, Population growth rate	Sep 2, 2025	Sep 2, 2025	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
3613	1770: Decrease, MMP	40: Mitochondrial ATP production, decreased	Sep 2, 2025	Sep 2, 2025	1 AOP 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
3614	1115: Increase, ROS	112: Antagonism, Estrogen receptor	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3615	495: Repressed expression of steroidogenic enzymes	1690: Decrease, circulating testosterone levels	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway

Key Event Relationships (KERs)

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