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Showing 2951 to 2975 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3616	1392: Increase, Oxidative Stress	495: Repressed expression of steroidogenic enzymes	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3617	26: Antagonism, Androgen receptor	2080: Impaired, blood testis barrier	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3618	2080: Impaired, blood testis barrier	520: Decreased sperm quantity or quality in the adult, Decreased fertility	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3619	520: Decreased sperm quantity or quality in the adult, Decreased fertility	1863: Decrease, Reproduction	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3620	1690: Decrease, circulating testosterone levels	1758: Impaired, Spermatogenesis	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3621	1758: Impaired, Spermatogenesis	520: Decreased sperm quantity or quality in the adult, Decreased fertility	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3622	1758: Impaired, Spermatogenesis	1863: Decrease, Reproduction	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3623	495: Repressed expression of steroidogenic enzymes	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Sep 3, 2025	Sep 3, 2025	None
3624	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	1696: Decrease of egg production and cummulative fecundity	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3625	1696: Decrease of egg production and cummulative fecundity	1863: Decrease, Reproduction	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3626	1066: Promotion, SIX1 positive progenitor cells in endometrium	1068: Endometrial squamous metaplasia, Increase	Sep 3, 2025	Sep 18, 2025	1 AOP 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
3627	1066: Promotion, SIX1 positive progenitor cells in endometrium	772: Increase, Hyperplasia (glandular epithelial cells of endometrium)	Sep 3, 2025	Sep 18, 2025	1 AOP 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
3628	2274: Androgen receptor activation, increased	2365: AGD, increased	Sep 5, 2025	Sep 5, 2025	1 AOP 547: Androgen receptor agonism leading to long anogenital distance in female offspring
3629	2362: Redox cycling	2363: Mito ROS dysfunction	Sep 7, 2025	Oct 3, 2025	1 AOP 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
3632	1392: Increase, Oxidative Stress	1767: Increase, Protein oxidation	Sep 8, 2025	Sep 8, 2025	7 AOPs 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
3633	1767: Increase, Protein oxidation	1446: Decrease, Coupling of OXPHOS	Sep 8, 2025	Sep 8, 2025	3 AOPs 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
3634	1767: Increase, Protein oxidation	179: Decrease, Fatty acid β-oxidation	Sep 8, 2025	Sep 8, 2025	3 AOPs 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
3635	179: Decrease, Fatty acid β-oxidation	1771: Decrease, ATP pool	Sep 8, 2025	Sep 8, 2025	3 AOPs 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation
3636	1767: Increase, Protein oxidation	1505: Cell cycle disruption	Sep 8, 2025	Sep 8, 2025	1 AOP 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption
3637	1542: Inhibition, Mitochondrial complex III	177: Increase, Mitochondrial dysfunction	Sep 24, 2025	Oct 2, 2025	1 AOP 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits
3638	2258: Inhibition, monocarboxylate transporter 8 (MCT8)	280: T4 in neuronal tissue, Decreased	Sep 29, 2025	Sep 29, 2025	None
3639	1267: Decrease, Ecdysis motor program activity	993: Decrease, Abdominal muscle contraction	Sep 29, 2025	Sep 29, 2025	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
3640	103: Increase, EcR hyperactivation	2373: Increase, Mis-timed EcR-responsive NR cascade	Sep 29, 2025	Sep 29, 2025	1 AOP 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
3641	2373: Increase, Mis-timed EcR-responsive NR cascade	988: Decrease, Circulating ETH	Sep 29, 2025	Sep 29, 2025	1 AOP 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
3642	2374: Increase, EcR antagonism	2375: Decrease, Mis-timed EcR-responsive NR cascade	Sep 29, 2025	Sep 29, 2025	2 AOPs 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1

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