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All KERs

Showing 3001 to 3025 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3668	2379: Disruption, regulatory function of dopamine signaling components.	2380: Increase, dopamine transporter gene	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3669	2379: Disruption, regulatory function of dopamine signaling components.	2381: Increase, dopamine receptor gene	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3670	2380: Increase, dopamine transporter gene	746: Increase, Dopaminergic activity	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3671	2381: Increase, dopamine receptor gene	746: Increase, Dopaminergic activity	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3672	746: Increase, Dopaminergic activity	602: Increased, Ataxia, paralysis, or hyperactivity	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3673	602: Increased, Ataxia, paralysis, or hyperactivity	1005: Reduced, Swimming performance	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3674	1005: Reduced, Swimming performance	2382: Increase, nerve spasm	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3675	227: Activation, PPARα	1312: Increase, Fatty acid β-oxidation	Oct 30, 2025	Oct 30, 2025	2 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
3676	1312: Increase, Fatty acid β-oxidation	1446: Decrease, Coupling of OXPHOS	Oct 30, 2025	Oct 30, 2025	2 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
3677	1771: Decrease, ATP pool	2384: Decrease, Vascular integrity	Oct 30, 2025	Oct 30, 2025	1 AOP 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate
3678	2384: Decrease, Vascular integrity	2383: Increase, Hemopericardium	Oct 30, 2025	Oct 30, 2025	2 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
3679	2383: Increase, Hemopericardium	947: Increase, Early Life Stage Mortality	Oct 30, 2025	Oct 30, 2025	3 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
3680	1115: Increase, ROS	2384: Decrease, Vascular integrity	Oct 30, 2025	Oct 30, 2025	1 AOP 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
3681	227: Activation, PPARα	948: reduced production, VEGF	Oct 30, 2025	Oct 30, 2025	1 AOP 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
3682	948: reduced production, VEGF	28: Reduction, Angiogenesis	Oct 30, 2025	Oct 30, 2025	1 AOP 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
3683	28: Reduction, Angiogenesis	2383: Increase, Hemopericardium	Oct 30, 2025	Oct 30, 2025	1 AOP 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
3684	2385: Suppression of Keap1 cysteine oxidation	1417: NFE2/Nrf2 repression	Nov 4, 2025	Nov 4, 2025	1 AOP 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
3685	1417: NFE2/Nrf2 repression	2386: Lipid-peroxidation overload	Nov 4, 2025	Nov 4, 2025	None
3686	2386: Lipid-peroxidation overload	1994: Ferroptosis	Nov 4, 2025	Nov 4, 2025	None
3687	1994: Ferroptosis	902: Inflammation, Liver	Nov 4, 2025	Nov 4, 2025	1 AOP 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
3688	2387: Nuclear receptor binding / steroidogenic enzyme interference	2389: Altered steroidogenesis	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3689	2388: photoproducts generate ROS	1392: Increase, Oxidative Stress	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3690	1392: Increase, Oxidative Stress	2363: Mito ROS dysfunction	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3691	2363: Mito ROS dysfunction	1262: Apoptosis	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3692	2389: Altered steroidogenesis	2390: reproductive hormonal Imbalance	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways

Key Event Relationships (KERs)

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