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Showing 3026 to 3050 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3693	1262: Apoptosis	2391: Reduced fertility	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3694	2390: reproductive hormonal Imbalance	2391: Reduced fertility	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3695	2388: photoproducts generate ROS	2389: Altered steroidogenesis	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3696	2388: photoproducts generate ROS	2363: Mito ROS dysfunction	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
3697	1507: Activation of PPARγ	202: Inhibition, Nuclear factor kappa B (NF-kB)	Dec 3, 2025	Dec 3, 2025	None
3698	202: Inhibition, Nuclear factor kappa B (NF-kB)	2394: Lower survival B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3699	202: Inhibition, Nuclear factor kappa B (NF-kB)	2395: Diminished proliferation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3700	202: Inhibition, Nuclear factor kappa B (NF-kB)	2396: Diminished differentiation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3701	2396: Diminished differentiation of activated B lymphocytes	2398: Reduced antibody production	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3702	2398: Reduced antibody production	2397: Diminished vaccine response	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3703	2394: Lower survival B lymphocytes	2395: Diminished proliferation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3704	2395: Diminished proliferation of activated B lymphocytes	2396: Diminished differentiation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3705	26: Antagonism, Androgen receptor	2393: AR transcriptional activity in GT tissues, reduced	Dec 16, 2025	Apr 8, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
3706	2393: AR transcriptional activity in GT tissues, reduced	2399: FGF10/FGFR2-IIIb signaling in genital tissue, reduced	Dec 16, 2025	May 7, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
3707	2399: FGF10/FGFR2-IIIb signaling in genital tissue, reduced	2400: Preputial epithelial morphogenesis, disrupted	Dec 16, 2025	Jun 4, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
3708	2400: Preputial epithelial morphogenesis, disrupted	2401: Male PPS, failed/delayed	Dec 16, 2025	Dec 16, 2025	1 AOP 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
3709	2342: Fe-S cluster assembly, impaired	178: Mitochondrial electron transport chain, disrupted	Jan 7, 2026	Jan 7, 2026	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
3710	2341: TCA cycle, disrupted	178: Mitochondrial electron transport chain, disrupted	Jan 7, 2026	Jan 7, 2026	1 AOP 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
3711	1028: Activation of specific nuclear receptors, PPAR-gamma activation	202: Inhibition, Nuclear factor kappa B (NF-kB)	Jan 16, 2026	Jan 16, 2026	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3712	1417: NFE2/Nrf2 repression	1445: Increase, LPO	Jan 19, 2026	Jan 19, 2026	1 AOP 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
3713	1445: Increase, LPO	902: Inflammation, Liver	Jan 19, 2026	Jan 19, 2026	1 AOP 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
3714	1985: Increased Kisspeptin levels in AVPV	1047: Increased, secretion of GnRH from hypothalamus	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3715	1047: Increased, secretion of GnRH from hypothalamus	2137: Increase, Gonadotropins concentration in plasma	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3716	2137: Increase, Gonadotropins concentration in plasma	2402: Increased, E2 production in ovaries	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3717	2402: Increased, E2 production in ovaries	2294: Plasma E2, increased	Jan 29, 2026	Jun 2, 2026	4 AOPs 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle

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