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All KERs

Showing 3076 to 3100 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3743	2408: Increase, Adipose lipolysis	465: Increased, FA Influx	Feb 24, 2026	Feb 24, 2026	3 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
3744	465: Increased, FA Influx	459: Increase, Liver steatosis	Feb 24, 2026	Feb 24, 2026	3 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
3745	2405: Increase, Hepatocellular lipotoxicity	1392: Increase, Oxidative Stress	Feb 24, 2026	Feb 24, 2026	2 AOPs 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress
3746	2294: Plasma E2, increased	2413: Increased, uterine weight	Mar 13, 2026	Jun 2, 2026	1 AOP 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining
3747	2371: Increased cortisol	1335: Reduced, BDNF	Mar 19, 2026	Mar 19, 2026	1 AOP 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
3748	2414: COL3A1 Signaling Pathway	1195: modulation, Extracellular Matrix Composition	Mar 25, 2026	Jun 4, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3749	1195: modulation, Extracellular Matrix Composition	870: Increase, Cell Proliferation	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3750	870: Increase, Cell Proliferation	1395: Liver Cancer	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3751	87: Release, Cytokine	1263: Necrosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3752	87: Release, Cytokine	1262: Apoptosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3753	87: Release, Cytokine	2009: Activation, inflammation pathway	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3754	1263: Necrosis	2009: Activation, inflammation pathway	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3755	1967: Pyroptosis	2009: Activation, inflammation pathway	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3756	2009: Activation, inflammation pathway	344: Increase, Liver fibrosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3757	1195: modulation, Extracellular Matrix Composition	344: Increase, Liver fibrosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3758	1115: Increase, ROS	1967: Pyroptosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3759	1262: Apoptosis	344: Increase, Liver fibrosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3760	1262: Apoptosis	1395: Liver Cancer	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3761	2294: Plasma E2, increased	2415: Precocious puberty	Mar 26, 2026	Jun 2, 2026	1 AOP 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release
3762	373: Formation, Pro-mutagenic DNA Adducts	1194: Increase, DNA Damage	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
3763	1194: Increase, DNA Damage	177: Increase, Mitochondrial dysfunction	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
3764	149: Increase, Inflammation	1825: Increase, Cell death	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
3765	1825: Increase, Cell death	1097: Occurrence, renal proximal tubular necrosis	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
3766	1097: Occurrence, renal proximal tubular necrosis	759: Increased, Kidney Failure	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
3767	177: Increase, Mitochondrial dysfunction	188: Neuroinflammation	Apr 2, 2026	Apr 2, 2026	1 AOP 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)

Key Event Relationships (KERs)

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