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Showing 3076 to 3100 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3752	87: Release, Cytokine	1262: Apoptosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3753	87: Release, Cytokine	2009: Activation, inflammation pathway	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3754	1263: Necrosis	2009: Activation, inflammation pathway	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3755	1967: Pyroptosis	2009: Activation, inflammation pathway	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3756	2009: Activation, inflammation pathway	344: Increase, Liver fibrosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3757	1195: modulation, Extracellular Matrix Composition	344: Increase, Liver fibrosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3758	1115: Increase, ROS	1967: Pyroptosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3759	1262: Apoptosis	344: Increase, Liver fibrosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3760	1262: Apoptosis	1395: Liver Cancer	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3761	2294: Plasma E2, increased	2415: Precocious puberty	Mar 26, 2026	Mar 26, 2026	1 AOP 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release
3762	373: Formation, Pro-mutagenic DNA Adducts	1194: Increase, DNA Damage	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
3763	1194: Increase, DNA Damage	177: Increase, Mitochondrial dysfunction	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
3764	149: Increase, Inflammation	1825: Increase, Cell death	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
3765	1825: Increase, Cell death	1097: Occurrence, renal proximal tubular necrosis	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
3766	1097: Occurrence, renal proximal tubular necrosis	759: Increased, Kidney Failure	Mar 29, 2026	Mar 29, 2026	1 AOP 472: DNA adduct formation leading to kidney failure
3767	177: Increase, Mitochondrial dysfunction	188: Neuroinflammation	Apr 2, 2026	Apr 2, 2026	1 AOP 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
3768	386: Neuronal network function, Decreased	2416: ALS	Apr 2, 2026	Apr 2, 2026	1 AOP 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
3770	1075: prolonged, estrus cycle	406: decreased, Fertility	Apr 6, 2026	Apr 6, 2026	1 AOP 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3769	2294: Plasma E2, increased	1075: prolonged, estrus cycle	Apr 6, 2026	Apr 6, 2026	1 AOP 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
3488	2298: Decrease, intratesticular testosterone	2082: Hypospadias	Feb 15, 2025	Apr 7, 2026	1 AOP 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring
3350	1690: Decrease, circulating testosterone levels	2082: Hypospadias	Oct 1, 2024	Apr 7, 2026	1 AOP 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring
3771	97: Alkylation, DNA	1757: Reduce, Sperm count	Apr 7, 2026	Apr 7, 2026	None
3705	26: Antagonism, Androgen receptor	2393: AR transcriptional activity in GT tissues, reduced	Dec 16, 2025	Apr 8, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
3772	1472: Decrease, ATP production	1521: Decrease, Growth	Apr 10, 2026	Apr 10, 2026	1 AOP 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
3773	1065: Activation, ERα	2417: Increased, differentiation to ovaries	Apr 17, 2026	Apr 17, 2026	1 AOP 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries

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