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Showing 3101 to 3125 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3768 386: Neuronal network function, Decreased 2416: ALS Apr 2, 2026 Apr 2, 2026
3769 2294: Plasma E2, increased 1075: prolonged, estrus cycle Apr 6, 2026 Apr 6, 2026
3770 1075: prolonged, estrus cycle 406: decreased, Fertility Apr 6, 2026 Apr 6, 2026
3771 97: Alkylation, DNA 1757: Reduce, Sperm count Apr 7, 2026 Apr 7, 2026 None
3772 1472: Decrease, ATP production 1521: Decrease, Growth Apr 10, 2026 Apr 10, 2026
3773 1065: Activation, ERα 2417: Increased, differentiation to ovaries Apr 17, 2026 Apr 17, 2026
3774 2417: Increased, differentiation to ovaries 2418: Increased, female-biased sex ratio Apr 17, 2026 Apr 17, 2026
3775 2421: FXR inhibition 2422: Decreased FGF15/FGF19 Apr 23, 2026 Apr 23, 2026
3776 1881: Decreased, atRA concentration 2419: Decreased, RAR activation Apr 24, 2026 Apr 24, 2026
3777 2419: Decreased, RAR activation 1882: Disrupted, meiotic initiation in oocyte Apr 24, 2026 Apr 24, 2026
3778 1887: CYP26B1, inhibition 1888: increased atRA concentration Apr 24, 2026 Apr 24, 2026
3779 1888: increased atRA concentration 2420: Increased, RAR activation Apr 24, 2026 Apr 24, 2026
3780 2420: Increased, RAR activation 1889: premature meiosis, male germ cells Apr 24, 2026 Apr 24, 2026
3781 1889: premature meiosis, male germ cells 1890: Germ cell loss, male Apr 24, 2026 Apr 24, 2026
3782 1890: Germ cell loss, male 1757: Reduce, Sperm count Apr 24, 2026 Apr 24, 2026
3783 1757: Reduce, Sperm count 406: decreased, Fertility Apr 24, 2026 Apr 24, 2026
3784 2422: Decreased FGF15/FGF19 2424: Hepatic CYP7A1, increased Apr 27, 2026 Apr 27, 2026
3785 2424: Hepatic CYP7A1, increased 2425: Intrahepatic bile acids, increased Apr 27, 2026 Apr 27, 2026
3786 2425: Intrahepatic bile acids, increased 2426: BSEP (ABCB11), decreased Apr 27, 2026 Apr 27, 2026
3787 2426: BSEP (ABCB11), decreased 2427: Bile acid composition, altered Apr 27, 2026 Apr 27, 2026
3788 2427: Bile acid composition, altered 1931: Disruption of the intestinal barrier Apr 27, 2026 Apr 27, 2026
3789 1931: Disruption of the intestinal barrier 2428: PAMPs, increased Apr 27, 2026 Apr 27, 2026
3790 2428: PAMPs, increased 1392: Increase, Oxidative Stress Apr 27, 2026 Apr 27, 2026
3791 1392: Increase, Oxidative Stress 902: Inflammation, Liver Apr 27, 2026 Apr 27, 2026
3792 902: Inflammation, Liver 1931: Disruption of the intestinal barrier Apr 27, 2026 Apr 27, 2026