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All KERs

Showing 3101 to 3125 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3774	2417: Increased, differentiation to ovaries	2418: Increased, female-biased sex ratio	Apr 17, 2026	Apr 17, 2026	1 AOP 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
68	55: Cell injury/death	265: Increase, HSC activation	Nov 29, 2016	Apr 21, 2026	2 AOPs 38: Protein Alkylation leading to Liver Fibrosis 494: AhR activation leading to liver fibrosis
3775	2421: FXR inhibition	2422: Decreased FGF15/FGF19	Apr 23, 2026	Apr 23, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3776	1881: Decreased, atRA concentration	2419: Decreased, RAR activation	Apr 24, 2026	Apr 24, 2026	1 AOP 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia
3777	2419: Decreased, RAR activation	1882: Disrupted, meiotic initiation in oocyte	Apr 24, 2026	Apr 24, 2026	1 AOP 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia
3778	1887: CYP26B1, inhibition	1888: increased atRA concentration	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3779	1888: increased atRA concentration	2420: Increased, RAR activation	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3780	2420: Increased, RAR activation	1889: premature meiosis, male germ cells	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3781	1889: premature meiosis, male germ cells	1890: Germ cell loss, male	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3782	1890: Germ cell loss, male	1757: Reduce, Sperm count	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3783	1757: Reduce, Sperm count	406: decreased, Fertility	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3784	2422: Decreased FGF15/FGF19	2424: Hepatic CYP7A1, increased	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3785	2424: Hepatic CYP7A1, increased	2425: Intrahepatic bile acids, increased	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3786	2425: Intrahepatic bile acids, increased	2426: BSEP (ABCB11), decreased	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3787	2426: BSEP (ABCB11), decreased	2427: Bile acid composition, altered	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3788	2427: Bile acid composition, altered	1931: Disruption of the intestinal barrier	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3789	1931: Disruption of the intestinal barrier	2428: PAMPs, increased	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
1503	424: Inhibition, Na+/I- symporter (NIS)	341: Impairment, Learning and memory	May 10, 2017	Apr 27, 2026	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
1506	277: TH synthesis, Decreased	341: Impairment, Learning and memory	May 10, 2017	Apr 27, 2026	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
403	281: T4 in serum, Decreased	402: Cognitive function, decreased	Nov 29, 2016	Apr 27, 2026	4 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
3790	2428: PAMPs, increased	1392: Increase, Oxidative Stress	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3791	1392: Increase, Oxidative Stress	902: Inflammation, Liver	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3792	902: Inflammation, Liver	1931: Disruption of the intestinal barrier	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3793	902: Inflammation, Liver	1489: Increase, Steatohepatitis	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3794	1417: NFE2/Nrf2 repression	2421: FXR inhibition	Apr 28, 2026	Apr 28, 2026	1 AOP 232: NFE2/Nrf2 repression to steatosis

Key Event Relationships (KERs)

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