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Showing 3151 to 3175 of 3182 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3824	2442: Abnormal lipid accumulation	2443: Hepatocyte injury	Jul 9, 2026	Jul 9, 2026	None
3825	2443: Hepatocyte injury	1995: Abnormal lipid metabolism	Jul 9, 2026	Jul 9, 2026	None
3826	2435: Myocardial and vascular structural remodeling	2445: Blood pressure	Jul 24, 2026	Jul 24, 2026	1 AOP 645: Binding and activation of AhR lead to cardiovascular aging
3827	2441: Increased fatty acid synthesis and transport	2446: lipid accumulation	Jul 24, 2026	Jul 24, 2026	1 AOP 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
3828	1824: Decrease, FAO	2446: lipid accumulation	Jul 24, 2026	Jul 24, 2026	1 AOP 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
3829	1392: Increase, Oxidative Stress	786: Increase, Cytotoxicity (hepatocytes)	Jul 24, 2026	Jul 24, 2026	1 AOP 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
3830	2446: lipid accumulation	786: Increase, Cytotoxicity (hepatocytes)	Jul 24, 2026	Jul 24, 2026	1 AOP 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
3831	786: Increase, Cytotoxicity (hepatocytes)	1995: Abnormal lipid metabolism	Jul 24, 2026	Jul 24, 2026	1 AOP 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
3832	530: Decreased, GnRH pulsatility/release	1986: Decreased, Gonadotropins	Jul 28, 2026	Aug 7, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3833	1046: Suppression, Estrogen receptor (ER) activity	2152: Epigenetic modification process	Jul 28, 2026	Jul 28, 2026	1 AOP 651: Suppression, Estrogen receptor (ER) activity leads to Impaired, Spermatogenesis via epigenetic modifications
3834	2152: Epigenetic modification process	1758: Impaired, Spermatogenesis	Jul 28, 2026	Jul 28, 2026	1 AOP 651: Suppression, Estrogen receptor (ER) activity leads to Impaired, Spermatogenesis via epigenetic modifications
3835	2444: Progesterone resistance	149: Increase, Inflammation	Aug 4, 2026	Aug 4, 2026	1 AOP 577: AhR activation leading to endometriosis
3836	18: Activation, AhR	2444: Progesterone resistance	Aug 5, 2026	Aug 5, 2026	1 AOP 577: AhR activation leading to endometriosis
3837	1445: Increase, LPO	1812: Increase, Cyt c release	Aug 20, 2026	Aug 20, 2026	1 AOP 647: ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response
3838	1767: Increase, Protein oxidation	1815: Increase, ER stress	Aug 20, 2026	Aug 20, 2026	1 AOP 647: ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response
3839	1815: Increase, ER stress	2188: Caspase activation	Aug 20, 2026	Aug 20, 2026	1 AOP 647: ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response
3840	2188: Caspase activation	55: Cell injury/death	Aug 20, 2026	Aug 20, 2026	1 AOP 647: ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response
3841	2448: IDE inhibition	2449: Abeta accumulation	Aug 31, 2026	Aug 31, 2026	1 AOP 652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
3842	2449: Abeta accumulation	1943: p-Tau	Aug 31, 2026	Aug 31, 2026	1 AOP 652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
3843	1943: p-Tau	1944: Dysfunctional synapses	Aug 31, 2026	Aug 31, 2026	1 AOP 652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
3844	1944: Dysfunctional synapses	2450: Cognitive Decline (Adult)	Aug 31, 2026	Aug 31, 2026	1 AOP 652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
3845	2449: Abeta accumulation	2450: Cognitive Decline (Adult)	Aug 31, 2026	Aug 31, 2026	1 AOP 652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
3846	2371: Increased cortisol	381: BDNF, Reduced	Sep 9, 2026	Sep 9, 2026	1 AOP 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
3847	381: BDNF, Reduced	1330: Decreased, neuroplasticity	Sep 9, 2026	Sep 9, 2026	2 AOPs 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression 221: Mental stress to depression
3848	122: Increase, GR activation	381: BDNF, Reduced	Sep 9, 2026	Sep 9, 2026	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)

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