AOP-Wiki

API

All KERs

Showing 3151 to 3175 of 3188 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2958	1495: Interaction with the lung cell membrane	1438: Increased transcription of genes encoding acute phase proteins	Jul 4, 2023	Aug 11, 2026	1 AOP 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
2959	1495: Interaction with the lung cell membrane	1439: Systemic acute phase response	Jul 4, 2023	Aug 11, 2026	1 AOP 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
2960	1495: Interaction with the lung cell membrane	1443: Atherosclerosis	Jul 4, 2023	Aug 11, 2026	1 AOP 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
3052	1496: Increased proinflammatory mediators	1439: Systemic acute phase response	Sep 19, 2023	Aug 11, 2026	1 AOP 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
3219	18: Activation, AhR	459: Increase, Liver steatosis	May 14, 2024	Aug 13, 2026	1 AOP 494: AhR activation leading to liver fibrosis
3774	2417: Increased, differentiation to ovaries	2418: Increased, female-biased sex ratio	Apr 17, 2026	Aug 17, 2026	1 AOP 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
3773	1065: Activation, ERα	2417: Increased, differentiation to ovaries	Apr 17, 2026	Aug 17, 2026	1 AOP 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
3837	1445: Increase, LPO	1812: Increase, Cyt c release	Aug 20, 2026	Aug 20, 2026	1 AOP 647: ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response
3838	1767: Increase, Protein oxidation	1815: Increase, ER stress	Aug 20, 2026	Aug 20, 2026	1 AOP 647: ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response
3839	1815: Increase, ER stress	2188: Caspase activation	Aug 20, 2026	Aug 20, 2026	1 AOP 647: ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response
3840	2188: Caspase activation	55: Cell injury/death	Aug 20, 2026	Aug 20, 2026	1 AOP 647: ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response
3628	2274: Androgen receptor activation, increased	2365: Anogenital distance (AGD), increased	Sep 5, 2025	Aug 30, 2026	1 AOP 547: Androgen receptor agonism leading to long anogenital distance (AGD) in female offspring
3841	2448: IDE inhibition	2449: Abeta accumulation	Aug 31, 2026	Aug 31, 2026	1 AOP 652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
3842	2449: Abeta accumulation	1943: p-Tau	Aug 31, 2026	Aug 31, 2026	1 AOP 652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
3843	1943: p-Tau	1944: Dysfunctional synapses	Aug 31, 2026	Aug 31, 2026	1 AOP 652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
3844	1944: Dysfunctional synapses	2450: Cognitive Decline	Aug 31, 2026	Aug 31, 2026	1 AOP 652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
3845	2449: Abeta accumulation	2450: Cognitive Decline	Aug 31, 2026	Aug 31, 2026	1 AOP 652: Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult)
3846	2371: Increased cortisol	381: BDNF, Reduced	Sep 9, 2026	Sep 9, 2026	1 AOP 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression
3847	381: BDNF, Reduced	1330: Decreased, neuroplasticity	Sep 9, 2026	Sep 9, 2026	2 AOPs 604: Binding of Alpha 1-Adrenergics to Agonists Leading to Depression 221: Mental stress to depression
3848	122: Increase, GR activation	381: BDNF, Reduced	Sep 9, 2026	Sep 9, 2026	1 AOP 214: Network of SSRIs (selective serotonin reuptake inhibitors)
3849	1396: Increased, glucocorticoid receptor activity	381: BDNF, Reduced	Sep 9, 2026	Sep 9, 2026	2 AOPs 221: Mental stress to depression 222: Mental stress to agitation
3850	1330: Decreased, neuroplasticity	381: BDNF, Reduced	Sep 9, 2026	Sep 9, 2026	None
3851	1328: Inactivated, 5-HTR	381: BDNF, Reduced	Sep 9, 2026	Sep 9, 2026	1 AOP 222: Mental stress to agitation
3852	2452: inhbition to MTP	2453: reduced lipid efflux	Sep 9, 2026	Sep 9, 2026	1 AOP 653: Inhibition to Microsomal Triglyceride Transfer Protein Leads to Steatosis
3853	2453: reduced lipid efflux	2446: lipid accumulation	Sep 9, 2026	Sep 9, 2026	1 AOP 653: Inhibition to Microsomal Triglyceride Transfer Protein Leads to Steatosis

Key Event Relationships (KERs)

All KERs