Key Event Relationships (KERs)

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Showing 26 to 50 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
378 397: Response, Keratinocytes 398: Activation, Dendritic Cells Nov 29, 2016 Nov 29, 2016 None
384 192: Altered, Neurophysiology 402: Cognitive function, decreased Nov 29, 2016 Nov 29, 2016
396 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) 3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Nov 29, 2016 Nov 29, 2016
402 409: Metabolism of AFB1, Production of Reactive Electrophiles 373: Formation, Pro-mutagenic DNA Adducts Nov 29, 2016 Nov 29, 2016
411 228: demethylation, PPARg promoter 54: Up Regulation, CD36 Nov 29, 2016 Nov 29, 2016
432 444: Increased, Atrioventricular block and bradycardia 351: Increased Mortality Nov 29, 2016 Nov 29, 2016 None
443 425: Thyroidal Iodide, Decreased 281: T4 in serum, Decreased Nov 29, 2016 Nov 29, 2016 None
454 10: ACh Synaptic Accumulation 444: Increased, Atrioventricular block and bradycardia Nov 29, 2016 Nov 29, 2016 None
547 493: Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts 376: Increased, Induced Mutations in Critical Genes Nov 29, 2016 Nov 29, 2016
549 376: Increased, Induced Mutations in Critical Genes 491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Nov 29, 2016 Nov 29, 2016
550 491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) 378: Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 29, 2016
551 373: Formation, Pro-mutagenic DNA Adducts 491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Nov 29, 2016 Nov 29, 2016
634 618: Decreased, Neuronal network function in adult brain 341: Impairment, Learning and memory Nov 29, 2016 Nov 29, 2016
647 352: N/A, Neurodegeneration 618: Decreased, Neuronal network function in adult brain Nov 29, 2016 Nov 29, 2016
864 844: Oxidation, Uroporphyrinogen 846: Accumulation, Highly carboxylated porphyrins Nov 29, 2016 Nov 29, 2016 None
867 845: Inhibition, UROD 844: Oxidation, Uroporphyrinogen Nov 29, 2016 Nov 29, 2016 None
874 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis Nov 29, 2016 Nov 29, 2016
875 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 854: Alterations, Cellular proliferation / hyperplasia Nov 29, 2016 Nov 29, 2016
876 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 856: Formation, Hepatocellular and Bile duct tumors Nov 29, 2016 Nov 29, 2016
877 857: Binding as antagonist, Antagonist binding to PPARalpha ligand binding domain 858: Decreased, PPARalpha transactivation of gene expression Nov 29, 2016 Nov 29, 2016 None
881 859: Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids 860: Decreased, Mitochondrial Fatty Acid Beta Oxidation Nov 29, 2016 Nov 29, 2016 None
882 860: Decreased, Mitochondrial Fatty Acid Beta Oxidation 861: Decreased, Ketogenesis (production of ketone bodies) Nov 29, 2016 Nov 29, 2016 None
886 867: Decrease, Intracellular pH 768: Increase, Cytotoxicity Nov 29, 2016 Nov 29, 2016
887 768: Increase, Cytotoxicity 868: Increase, Tissue Degeneration, Necrosis & Atrophy Nov 29, 2016 Nov 29, 2016
916 901: Infiltration, Inflammatory cells 902: Inflammation, Liver Nov 29, 2016 Nov 29, 2016 None