Key Event Relationships (KERs)

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Showing 51 to 75 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
919 875: Binding of agonist, Ionotropic glutamate receptors 388: Overactivation, NMDARs Nov 29, 2016 Nov 29, 2016
921 898: Disruption, Lysosome 209: Peptide Oxidation Nov 29, 2016 Nov 29, 2016 None
922 209: Peptide Oxidation 177: Increase, Mitochondrial dysfunction Nov 29, 2016 Nov 29, 2016 None
942 913: Activation, Epidermal Growth Factor Receptor 919: Occurrence, Transdifferentiation of ciliated epithelial cells Nov 29, 2016 Nov 29, 2016 None
948 209: Peptide Oxidation 926: Oxidation, Glutathione Nov 29, 2016 Nov 29, 2016 None
989 921: Goblet cell hyperplasia 943: Hypersecretion, Mucus Nov 29, 2016 Nov 29, 2016 None
990 920: Goblet cell metaplasia 943: Hypersecretion, Mucus Nov 29, 2016 Nov 29, 2016 None
991 962: Increase, Mucin production 943: Hypersecretion, Mucus Nov 29, 2016 Nov 29, 2016 None
994 87: Release, Cytokine 901: Infiltration, Inflammatory cells Nov 29, 2016 Nov 29, 2016 None
1271 1215: TRPA1 activation, TRPA1 Receptor 1218: Opening of calcium channel, Calcium influx Nov 29, 2016 Nov 29, 2016
1279 1222: SP (Substance P) release, Local increase of SP 1224: Non-neuronal production of TNF, Epithelial irritation Nov 29, 2016 Nov 29, 2016 None
1280 1218: Opening of calcium channel, Calcium influx 1222: SP (Substance P) release, Local increase of SP Nov 29, 2016 Nov 29, 2016 None
1281 1230: TRPV1 activation, TRPV1 1218: Opening of calcium channel, Calcium influx Nov 29, 2016 Nov 29, 2016 None
129 112: Antagonism, Estrogen receptor 285: Reduction, Vitellogenin synthesis in liver Nov 29, 2016 Nov 30, 2016
45 36: Inhibition, Aromatase 3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Nov 29, 2016 Nov 30, 2016
346 376: Increased, Induced Mutations in Critical Genes 378: Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 30, 2016
888 868: Increase, Tissue Degeneration, Necrosis & Atrophy 869: Increase, Respiratory or Squamous Metaplasia Nov 29, 2016 Dec 1, 2016
889 869: Increase, Respiratory or Squamous Metaplasia 870: Increase, Cell Proliferation Nov 29, 2016 Dec 1, 2016
894 876: Increase, Mutations in Critical Genes 872: Increase, Site of Contact Nasal Tumors Nov 29, 2016 Dec 1, 2016
895 870: Increase, Cell Proliferation 872: Increase, Site of Contact Nasal Tumors Nov 29, 2016 Dec 1, 2016
369 227: Activation, PPARα 266: Decrease, Steroidogenic acute regulatory protein (STAR) Nov 29, 2016 Dec 2, 2016
370 227: Activation, PPARα 289: Decrease, Translocator protein (TSPO) Nov 29, 2016 Dec 2, 2016
437 289: Decrease, Translocator protein (TSPO) 447: Reduction, Cholesterol transport in mitochondria Nov 29, 2016 Dec 2, 2016
438 447: Reduction, Cholesterol transport in mitochondria 413: Reduction, Testosterone synthesis in Leydig cells Nov 29, 2016 Dec 2, 2016
439 413: Reduction, Testosterone synthesis in Leydig cells 446: Reduction of testosterone Nov 29, 2016 Dec 2, 2016 None