Key Event Relationships (KERs)

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Showing 76 to 100 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
608 446: Reduction of testosterone 348: Malformation, Male reproductive tract Nov 29, 2016 Dec 2, 2016 None
405 348: Malformation, Male reproductive tract 406: decreased, Fertility Nov 29, 2016 Dec 2, 2016
995 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Nov 29, 2016 Dec 2, 2016
996 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects 854: Alterations, Cellular proliferation / hyperplasia Nov 29, 2016 Dec 2, 2016
997 854: Alterations, Cellular proliferation / hyperplasia 856: Formation, Hepatocellular and Bile duct tumors Nov 29, 2016 Dec 2, 2016
9 8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity 179: Decrease, Fatty acid β-oxidation Nov 29, 2016 Dec 3, 2016
77 66: Activation, ChREBP 89: Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
70 60: Induction, Chitin degradation and resorption 238: Induction, Pre-mature molting Nov 29, 2016 Dec 3, 2016 None
69 57: Proliferation, Cell proliferation in the absence of cytotoxicity 142: Hyperplasia, Hyperplasia Nov 29, 2016 Dec 3, 2016
62 52: Decreased, Calcium influx 341: Impairment, Learning and memory Nov 29, 2016 Dec 3, 2016 None
61 51: Inhibition, Ca++ ATPase 50: Increase, Ca++ (intracellular) Nov 29, 2016 Dec 3, 2016
60 50: Increase, Ca++ (intracellular) 178: Mitochondrial electron transport chain, disrupted Nov 29, 2016 Dec 3, 2016
59 49: Reduction, Ca and HCO3 transport to shell gland 106: Reduction, Eggshell thickness Nov 29, 2016 Dec 3, 2016
51 39: Increased Cholinergic Signaling 360: Decrease, Population growth rate Nov 29, 2016 Dec 3, 2016 None
19 18: Activation, AhR 80: Up Regulation, CYP1A1 Nov 29, 2016 Dec 3, 2016
18 18: Activation, AhR 17: Altered expression of AHR/ARNT pathway-dependent genes Nov 29, 2016 Dec 3, 2016 None
17 17: Altered expression of AHR/ARNT pathway-dependent genes 80: Up Regulation, CYP1A1 Nov 29, 2016 Dec 3, 2016 None
16 17: Altered expression of AHR/ARNT pathway-dependent genes 317: Altered, Cardiovascular development/function Nov 29, 2016 Dec 3, 2016 None
93 77: Production, Critical Metabolites (CGA 330050 and CGA 265307) 164: Induction, Liver “Dysfunctional” Changes by CGA 330050 Nov 29, 2016 Dec 3, 2016
116 103: Increase, EcR hyperactivation 60: Induction, Chitin degradation and resorption Nov 29, 2016 Dec 3, 2016 None
104 84: Up Regulation, CYP1B1 3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Nov 29, 2016 Dec 3, 2016 None
96 80: Up Regulation, CYP1A1 209: Peptide Oxidation Nov 29, 2016 Dec 3, 2016 None
95 79: Inhibition, Cyclooxygenase activity 243: Reduction, Prostaglandin E2 concentration Nov 29, 2016 Dec 3, 2016
108 87: Release, Cytokine 149: Increase, Inflammation Nov 29, 2016 Dec 3, 2016
197 183: Abnormal, Morphogenesis 366: Increased, Structural malformations Nov 29, 2016 Dec 3, 2016 None