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All KERs

Showing 101 to 125 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

277	250: Damaging, Red blood cells; hemolysis	161: Increase, Liver and splenic hemosiderosis	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
278	250: Damaging, Red blood cells; hemolysis	173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
279	250: Damaging, Red blood cells; hemolysis	246: Increase, RBC congestion in liver	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
280	252: Increase, Renal pathology due to VTG deposition	339: Altered, Larval development	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
284	258: Activation, SCD-1	89: Synthesis, De Novo Fatty Acid (FA)	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
287	261: Binding, SH-/selen-proteins	158: N/A, Interferences with SH-/selen-proteins	Nov 29, 2016	Dec 3, 2016	None
294	264: Activation, SREBP-1c	89: Synthesis, De Novo Fatty Acid (FA)	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
295	265: Increase, HSC activation	68: Increase, Collagen accumulation	Nov 29, 2016	Dec 5, 2018	8 AOPs 38: Protein Alkylation leading to Liver Fibrosis 144: Endocytic lysosomal uptake leading to liver fibrosis 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
296	366: Increased, Structural malformations	342: Increased, Lethality	Nov 29, 2016	Dec 3, 2016	None
298	269: Induction, Sustained Cell Proliferation	347: Formation, Liver tumor	Nov 29, 2016	Dec 3, 2016	1 AOP 32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
299	270: Induction, Sustained Hepatotoxicity	269: Induction, Sustained Cell Proliferation	Nov 29, 2016	Dec 3, 2016	1 AOP 32: Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
301	272: Activation/Proliferation, T-cells	312: N/A, Allergic contact dermatitis on challenge	Nov 29, 2016	Dec 3, 2016	None
302	274: Reduction, Testosterone synthesis by ovarian theca cells	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
303	276: Up Regulation, TGFbeta1 expression	68: Increase, Collagen accumulation	Nov 29, 2016	Dec 3, 2016	None
304	276: Up Regulation, TGFbeta1 expression	265: Increase, HSC activation	Nov 29, 2016	Nov 29, 2016	None
305	277: TH synthesis, Decreased	281: T4 in serum, Decreased	Nov 29, 2016	Oct 10, 2022	18 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 128: Kidney dysfunction by decreased thyroid hormone 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis 192: Pendrin inhibition leading to altered amphibian metamorphosis 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
309	279: Thyroperoxidase, Inhibition	277: TH synthesis, Decreased	Nov 29, 2016	Nov 4, 2022	8 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
312	281: T4 in serum, Decreased	280: T4 in neuronal tissue, Decreased	Nov 29, 2016	Apr 4, 2019	7 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
315	285: Reduction, Vitellogenin synthesis in liver	221: Reduction, Plasma vitellogenin concentrations	Nov 29, 2016	Mar 20, 2017	7 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
316	286: Altered, Transcription of genes by the AR	240: Feminisation or incomplete development, Primary and accessory male sex organs	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
317	286: Altered, Transcription of genes by the AR	310: Alteration, Wnt pathway	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
319	288: Activation of specific nuclear receptors, Transcriptional change	357: Cholestasis, Pathology	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
324	294: N/A, Unknown	57: Proliferation, Cell proliferation in the absence of cytotoxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 1: Uncharacterized liver damage leading to hepatocellular carcinoma
329	298: Insufficiency, Vascular	183: Abnormal, Morphogenesis	Nov 29, 2016	Dec 3, 2016	None
330	301: Binding, VEGF-A	304: Decreased, VegfR2	Nov 29, 2016	Dec 3, 2016	None

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