Key Event Relationships (KERs)

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Showing 126 to 150 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2534 1956: Binding to hERG channel 1958: Direct hERG channel blockage Dec 13, 2021 Dec 13, 2021 None
2535 1957: hERG channel biogenesis interference 1958: Direct hERG channel blockage Dec 13, 2021 Dec 13, 2021 None
2536 1957: hERG channel biogenesis interference 1959: Induction of hERG trafficking defects Dec 13, 2021 Dec 13, 2021 None
2537 1958: Direct hERG channel blockage 1960: Inhibition of Ikr Dec 13, 2021 Dec 13, 2021 None
2538 1959: Induction of hERG trafficking defects 1960: Inhibition of Ikr Dec 13, 2021 Dec 13, 2021 None
2539 1960: Inhibition of Ikr 1961: Prolongation of Action Potential Dec 13, 2021 Dec 13, 2021 None
2544 1954: Gut dysbiosis 1497: Recruitment of inflammatory cells Dec 15, 2021 Dec 15, 2021 None
2543 1497: Recruitment of inflammatory cells 1954: Gut dysbiosis Dec 15, 2021 Dec 15, 2021 None
2560 1777: Increase, Ovarian follicle breakdown 328: Decrease, Fecundity Feb 4, 2022 Feb 4, 2022 None
2420 281: T4 in serum, Decreased 753: Increase, Thyroid-stimulating hormone (TSH) Jul 7, 2021 Jul 7, 2021 None
2421 737: Decreased, Uptake of inorganic iodide 277: TH synthesis, Decreased Jul 7, 2021 Jul 7, 2021 None
2423 1021: Increased, T4/T3 catabolism 281: T4 in serum, Decreased Jul 7, 2021 Jul 7, 2021 None
2425 1023: Increased, Thyroid-stimulating hormone (TSH) 753: Increase, Thyroid-stimulating hormone (TSH) Jul 7, 2021 Jul 7, 2021 None
2426 1025: Increased, Hyperplasia (follicular cells) 741: Increase, Adenomas/carcinomas (follicular cell) Jul 7, 2021 Jul 7, 2021 None
2427 1024: Increased, Hypertrophy and proliferation (follicular cell) 740: Increase, Hyperplasia (follicular cells) Jul 7, 2021 Jul 7, 2021 None
2406 1878: Decreased, Eye size 351: Increased Mortality May 28, 2021 May 28, 2021 None
2428 295: Induction, Upregulation of glucuronyltransferase activity 1021: Increased, T4/T3 catabolism Jul 7, 2021 Jul 7, 2021 None
2516 1947: Pericyte dysfunction 1913: Endothelial cell dysfunction Oct 28, 2021 Oct 28, 2021 None
2513 1750: Increased inflammatory immune responses 1934: Heart attack Oct 28, 2021 Oct 28, 2021 None
2512 1666: dysfunction of microcirculation 1750: Increased inflammatory immune responses Oct 28, 2021 Oct 28, 2021 None
2511 1913: Endothelial cell dysfunction 1666: dysfunction of microcirculation Oct 28, 2021 Oct 28, 2021 None
2510 1738: SARS-CoV-2 cell entry 1913: Endothelial cell dysfunction Oct 28, 2021 Oct 28, 2021 None
2509 1948: Upregulation of ACE2 1738: SARS-CoV-2 cell entry Oct 28, 2021 Oct 28, 2021 None
2508 1535: Heart failure 1948: Upregulation of ACE2 Oct 28, 2021 Oct 28, 2021 None
2514 1535: Heart failure 1946: Altered mechanotransduction properties of pericytes Oct 28, 2021 Oct 28, 2021 None