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Showing 126 to 150 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

303	276: Up Regulation, TGFbeta1 expression	68: Increase, Collagen accumulation	Nov 29, 2016	Dec 3, 2016	None
304	276: Up Regulation, TGFbeta1 expression	265: Increase, HSC activation	Nov 29, 2016	Nov 29, 2016	None
305	277: TH synthesis, Decreased	281: T4 in serum, Decreased	Nov 29, 2016	Oct 10, 2022	18 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 128: Kidney dysfunction by decreased thyroid hormone 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis 192: Pendrin inhibition leading to altered amphibian metamorphosis 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
309	279: Thyroperoxidase, Inhibition	277: TH synthesis, Decreased	Nov 29, 2016	Nov 4, 2022	8 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
284	258: Activation, SCD-1	89: Synthesis, De Novo Fatty Acid (FA)	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
315	285: Reduction, Vitellogenin synthesis in liver	221: Reduction, Plasma vitellogenin concentrations	Nov 29, 2016	Mar 20, 2017	7 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
316	286: Altered, Transcription of genes by the AR	240: Feminisation or incomplete development, Primary and accessory male sex organs	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
317	286: Altered, Transcription of genes by the AR	310: Alteration, Wnt pathway	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
319	288: Activation of specific nuclear receptors, Transcriptional change	357: Cholestasis, Pathology	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
324	294: N/A, Unknown	57: Proliferation, Cell proliferation in the absence of cytotoxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 1: Uncharacterized liver damage leading to hepatocellular carcinoma
329	298: Insufficiency, Vascular	183: Abnormal, Morphogenesis	Nov 29, 2016	Dec 3, 2016	None
330	301: Binding, VEGF-A	304: Decreased, VegfR2	Nov 29, 2016	Dec 3, 2016	None
331	301: Binding, VEGF-A	305: Inhibition, VegfR2	Nov 29, 2016	Dec 3, 2016	None
332	302: Production, VEGF-A	301: Binding, VEGF-A	Nov 29, 2016	Dec 3, 2016	None
333	302: Production, VEGF-A	304: Decreased, VegfR2	Nov 29, 2016	Dec 3, 2016	None
334	304: Decreased, VegfR2	305: Inhibition, VegfR2	Nov 29, 2016	Dec 3, 2016	None
335	305: Inhibition, VegfR2	28: Reduction, Angiogenesis	Nov 29, 2016	Jul 20, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
261	238: Induction, Pre-mature molting	328: Decrease, Fecundity	Nov 29, 2016	Dec 3, 2016	None
236	209: Peptide Oxidation	134: Increase, Kupffer cell activation	Nov 29, 2016	Dec 3, 2016	None
242	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	21: Altered regulation, Alpha hemoglobin	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
243	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	118: Formation, Formation of hemoglobin adducts	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
245	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	250: Damaging, Red blood cells; hemolysis	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
248	214: Bile accumulation, Pathological condition	288: Activation of specific nuclear receptors, Transcriptional change	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
252	219: Reduction, Plasma 17beta-estradiol concentrations	285: Reduction, Vitellogenin synthesis in liver	Nov 29, 2016	Mar 20, 2017	5 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
253	219: Reduction, Plasma 17beta-estradiol concentrations	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	Nov 29, 2016	Nov 29, 2016	None

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