AOP-Wiki

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Showing 126 to 150 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

331	301: Binding, VEGF-A	305: Inhibition, VegfR2	Nov 29, 2016	Dec 3, 2016	None
332	302: Production, VEGF-A	301: Binding, VEGF-A	Nov 29, 2016	Dec 3, 2016	None
333	302: Production, VEGF-A	304: Decreased, VegfR2	Nov 29, 2016	Dec 3, 2016	None
334	304: Decreased, VegfR2	305: Inhibition, VegfR2	Nov 29, 2016	Dec 3, 2016	None
335	305: Inhibition, VegfR2	28: Reduction, Angiogenesis	Nov 29, 2016	Jul 20, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
336	307: Increase, Vitellogenin synthesis in liver	220: Increase, Plasma vitellogenin concentrations	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
337	309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development	78: Reduction, Cumulative fecundity and spawning	Nov 29, 2016	Mar 20, 2017	9 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
338	310: Alteration, Wnt pathway	240: Feminisation or incomplete development, Primary and accessory male sex organs	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
340	380: Activation, Pre-MIE: Metabolism of AFB1	373: Formation, Pro-mutagenic DNA Adducts	Nov 29, 2016	Dec 3, 2016	None
342	376: Increased, Induced Mutations in Critical Genes	377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H	Nov 29, 2016	Nov 29, 2016	None
343	377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Nov 29, 2016	None
344	373: Formation, Pro-mutagenic DNA Adducts	377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H	Nov 29, 2016	Dec 3, 2016	None
345	373: Formation, Pro-mutagenic DNA Adducts	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Nov 29, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
346	376: Increased, Induced Mutations in Critical Genes	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Nov 30, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
347	52: Decreased, Calcium influx	381: BDNF, Reduced	Nov 29, 2016	Jun 13, 2018	2 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
348	381: BDNF, Reduced	382: Aberrant, Dendritic morphology	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
350	384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Dec 3, 2016	None
351	376: Increased, Induced Mutations in Critical Genes	384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci	Nov 29, 2016	Nov 29, 2016	None
352	373: Formation, Pro-mutagenic DNA Adducts	384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci	Nov 29, 2016	Nov 29, 2016	None
353	381: BDNF, Reduced	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	2 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
354	381: BDNF, Reduced	383: Reduced, Presynaptic release of glutamate	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
355	55: Cell injury/death	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
356	382: Aberrant, Dendritic morphology	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
357	383: Reduced, Presynaptic release of glutamate	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
358	385: Synaptogenesis, Decreased	386: Neuronal network function, Decreased	Nov 29, 2016	May 25, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment

Key Event Relationships (KERs)

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