Key Event Relationships (KERs)

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Showing 126 to 150 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
159 147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 270: Induction, Sustained Hepatotoxicity Nov 29, 2016 Dec 3, 2016
170 164: Induction, Liver “Dysfunctional” Changes by CGA 330050 147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 Nov 29, 2016 Dec 3, 2016
168 158: N/A, Interferences with SH-/selen-proteins 130: Depletion, GSH Nov 29, 2016 Dec 3, 2016 None
169 161: Increase, Liver and splenic hemosiderosis 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number Nov 29, 2016 Dec 3, 2016
236 209: Peptide Oxidation 134: Increase, Kupffer cell activation Nov 29, 2016 Dec 3, 2016 None
280 252: Increase, Renal pathology due to VTG deposition 339: Altered, Larval development Nov 29, 2016 Dec 3, 2016
279 250: Damaging, Red blood cells; hemolysis 246: Increase, RBC congestion in liver Nov 29, 2016 Dec 3, 2016
278 250: Damaging, Red blood cells; hemolysis 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number Nov 29, 2016 Dec 3, 2016
277 250: Damaging, Red blood cells; hemolysis 161: Increase, Liver and splenic hemosiderosis Nov 29, 2016 Dec 3, 2016
272 246: Increase, RBC congestion in liver 173: N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number Nov 29, 2016 Dec 3, 2016
271 244: Alkylation, Protein 209: Peptide Oxidation Nov 29, 2016 Dec 3, 2016 None
268 243: Reduction, Prostaglandin E2 concentration 119: N/A, Gap Nov 29, 2016 Dec 3, 2016
266 240: Feminisation or incomplete development, Primary and accessory male sex organs 337: N/A, Impairment of reproductive capacity Nov 29, 2016 Dec 3, 2016
263 238: Induction, Pre-mature molting 351: Increased Mortality Nov 29, 2016 Dec 3, 2016 None
262 238: Induction, Pre-mature molting 350: Increase, Mortality Nov 29, 2016 Dec 3, 2016 None
260 233: Decreased, PPAR-gamma activation 140: Decreased, HSD17B10 expression Nov 29, 2016 Dec 3, 2016
242 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin 21: Altered regulation, Alpha hemoglobin Nov 29, 2016 Dec 3, 2016
243 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin 118: Formation, Formation of hemoglobin adducts Nov 29, 2016 Dec 3, 2016
245 213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin 250: Damaging, Red blood cells; hemolysis Nov 29, 2016 Dec 3, 2016
248 214: Bile accumulation, Pathological condition 288: Activation of specific nuclear receptors, Transcriptional change Nov 29, 2016 Dec 3, 2016
257 231: Decreased, PPAR-alpha activation 140: Decreased, HSD17B10 expression Nov 29, 2016 Dec 3, 2016
259 232: Decreased, PPAR-beta activation 140: Decreased, HSD17B10 expression Nov 29, 2016 Dec 3, 2016
261 238: Induction, Pre-mature molting 328: Decrease, Fecundity Nov 29, 2016 Dec 3, 2016 None
333 302: Production, VEGF-A 304: Decreased, VegfR2 Nov 29, 2016 Dec 3, 2016 None
334 304: Decreased, VegfR2 305: Inhibition, VegfR2 Nov 29, 2016 Dec 3, 2016 None