Key Event Relationships (KERs)

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Showing 151 to 175 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2515 1946: Altered mechanotransduction properties of pericytes 1947: Pericyte dysfunction Oct 28, 2021 Oct 28, 2021 None
2517 1787: Downregulation of ACE2 1935: Ang (1-7) levels reduced Oct 28, 2021 Oct 28, 2021 None
2518 1935: Ang (1-7) levels reduced 1936: Degradation of Ang-II reduced Oct 28, 2021 Oct 28, 2021 None
2519 1936: Degradation of Ang-II reduced 1741: Induced, Angiotensin (Ang) II accumulation Oct 28, 2021 Oct 28, 2021 None
2520 1741: Induced, Angiotensin (Ang) II accumulation 1853: Hyperactivation of ACE/Ang-II/AT1R axis Oct 28, 2021 Oct 28, 2021 None
2521 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1535: Heart failure Oct 28, 2021 Oct 28, 2021 None
2522 1739: Binding to ACE2 1937: ADAM17 induction Oct 28, 2021 Oct 28, 2021 None
2523 1937: ADAM17 induction 1938: ACE2 increased shedding Oct 28, 2021 Oct 28, 2021 None
2524 1938: ACE2 increased shedding 1935: Ang (1-7) levels reduced Oct 28, 2021 Oct 28, 2021 None
449 12: AchE Inhibition 444: Increased, Atrioventricular block and bradycardia Nov 29, 2016 Dec 3, 2016 None
428 351: Increased Mortality 442: Decreased, Population trajectory Nov 29, 2016 Dec 20, 2019 None
432 444: Increased, Atrioventricular block and bradycardia 351: Increased Mortality Nov 29, 2016 Nov 29, 2016 None
447 428: Delay, Developmental GABA shift 385: Synaptogenesis, Decreased Nov 29, 2016 Dec 3, 2016 None
434 39: Increased Cholinergic Signaling 351: Increased Mortality Nov 29, 2016 Dec 3, 2016 None
446 427: Down Regulation, K-Cl co-transporter 2 (KCC2) 428: Delay, Developmental GABA shift Nov 29, 2016 Dec 3, 2016 None
445 381: BDNF, Reduced 427: Down Regulation, K-Cl co-transporter 2 (KCC2) Nov 29, 2016 Dec 3, 2016 None
439 413: Reduction, Testosterone synthesis in Leydig cells 446: Reduction of testosterone Nov 29, 2016 Dec 2, 2016 None
443 425: Thyroidal Iodide, Decreased 281: T4 in serum, Decreased Nov 29, 2016 Nov 29, 2016 None
340 380: Activation, Pre-MIE: Metabolism of AFB1 373: Formation, Pro-mutagenic DNA Adducts Nov 29, 2016 Dec 3, 2016 None
342 376: Increased, Induced Mutations in Critical Genes 377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H Nov 29, 2016 Nov 29, 2016 None
343 377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H 378: Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 29, 2016 None
344 373: Formation, Pro-mutagenic DNA Adducts 377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H Nov 29, 2016 Dec 3, 2016 None
350 384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci 378: Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Dec 3, 2016 None
351 376: Increased, Induced Mutations in Critical Genes 384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Nov 29, 2016 Nov 29, 2016 None
352 373: Formation, Pro-mutagenic DNA Adducts 384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Nov 29, 2016 Nov 29, 2016 None