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Showing 151 to 175 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

359	386: Neuronal network function, Decreased	341: Impairment, Learning and memory	Nov 29, 2016	Jul 15, 2022	6 AOPs 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
360	387: Binding of agonist, NMDARs	388: Overactivation, NMDARs	Nov 29, 2016	Nov 29, 2016	None
361	388: Overactivation, NMDARs	389: Increased, Intracellular Calcium overload	Nov 29, 2016	Sep 10, 2023	4 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
362	389: Increased, Intracellular Calcium overload	177: Increase, Mitochondrial dysfunction	Nov 29, 2016	Nov 29, 2016	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
363	177: Increase, Mitochondrial dysfunction	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	4 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction
364	55: Cell injury/death	352: N/A, Neurodegeneration	Nov 29, 2016	Sep 10, 2023	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
365	55: Cell injury/death	188: Neuroinflammation	Nov 29, 2016	Jul 15, 2022	3 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
366	279: Thyroperoxidase, Inhibition	281: T4 in serum, Decreased	Nov 29, 2016	Nov 18, 2025	4 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
368	352: N/A, Neurodegeneration	386: Neuronal network function, Decreased	Nov 29, 2016	Dec 3, 2016	None
369	227: Activation, PPARα	266: Decrease, Steroidogenic acute regulatory protein (STAR)	Nov 29, 2016	Dec 2, 2016	1 AOP 18: PPARα activation in utero leading to impaired fertility in males
370	227: Activation, PPARα	289: Decrease, Translocator protein (TSPO)	Nov 29, 2016	Dec 2, 2016	1 AOP 18: PPARα activation in utero leading to impaired fertility in males
376	396: Covalent Binding, Protein	397: Response, Keratinocytes	Nov 29, 2016	Dec 3, 2016	None
377	396: Covalent Binding, Protein	398: Activation, Dendritic Cells	Nov 29, 2016	Nov 5, 2020	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
378	397: Response, Keratinocytes	398: Activation, Dendritic Cells	Nov 29, 2016	Nov 29, 2016	None
379	398: Activation, Dendritic Cells	272: Activation/Proliferation, T-cells	Nov 29, 2016	Aug 22, 2022	2 AOPs 40: Covalent Protein binding leading to Skin Sensitisation 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
380	397: Response, Keratinocytes	272: Activation/Proliferation, T-cells	Nov 29, 2016	Dec 3, 2016	None
383	279: Thyroperoxidase, Inhibition	402: Cognitive function, decreased	Nov 29, 2016	Dec 3, 2016	None
384	192: Altered, Neurophysiology	402: Cognitive function, decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
385	122: Increase, GR activation	145: Induction, IKB inhibitory protein	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
386	145: Induction, IKB inhibitory protein	202: Inhibition, Nuclear factor kappa B (NF-kB)	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
387	202: Inhibition, Nuclear factor kappa B (NF-kB)	152: Suppression, Inflammatory cytokines	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
388	152: Suppression, Inflammatory cytokines	168: Decreased, Lymphocytes	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
389	168: Decreased, Lymphocytes	323: Increased, Disease susceptibility	Nov 29, 2016	Dec 3, 2016	None
390	168: Decreased, Lymphocytes	403: Suppression, Immune system	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
392	219: Reduction, Plasma 17beta-estradiol concentrations	405: disrupted, ovarian cycle	Nov 29, 2016	Dec 3, 2016	1 AOP 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female

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