Key Event Relationships (KERs)

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Showing 151 to 175 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
332 302: Production, VEGF-A 301: Binding, VEGF-A Nov 29, 2016 Dec 3, 2016 None
331 301: Binding, VEGF-A 305: Inhibition, VegfR2 Nov 29, 2016 Dec 3, 2016 None
330 301: Binding, VEGF-A 304: Decreased, VegfR2 Nov 29, 2016 Dec 3, 2016 None
329 298: Insufficiency, Vascular 183: Abnormal, Morphogenesis Nov 29, 2016 Dec 3, 2016 None
324 294: N/A, Unknown 57: Proliferation, Cell proliferation in the absence of cytotoxicity Nov 29, 2016 Dec 3, 2016
319 288: Activation of specific nuclear receptors, Transcriptional change 357: Cholestasis, Pathology Nov 29, 2016 Dec 3, 2016
317 286: Altered, Transcription of genes by the AR 310: Alteration, Wnt pathway Nov 29, 2016 Dec 3, 2016
316 286: Altered, Transcription of genes by the AR 240: Feminisation or incomplete development, Primary and accessory male sex organs Nov 29, 2016 Dec 3, 2016
284 258: Activation, SCD-1 89: Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
303 276: Up Regulation, TGFbeta1 expression 68: Increase, Collagen accumulation Nov 29, 2016 Dec 3, 2016 None
301 272: Activation/Proliferation, T-cells 312: N/A, Allergic contact dermatitis on challenge Nov 29, 2016 Dec 3, 2016 None
287 261: Binding, SH-/selen-proteins 158: N/A, Interferences with SH-/selen-proteins Nov 29, 2016 Dec 3, 2016 None
294 264: Activation, SREBP-1c 89: Synthesis, De Novo Fatty Acid (FA) Nov 29, 2016 Dec 3, 2016
296 366: Increased, Structural malformations 342: Increased, Lethality Nov 29, 2016 Dec 3, 2016 None
298 269: Induction, Sustained Cell Proliferation 347: Formation, Liver tumor Nov 29, 2016 Dec 3, 2016
299 270: Induction, Sustained Hepatotoxicity 269: Induction, Sustained Cell Proliferation Nov 29, 2016 Dec 3, 2016
434 39: Increased Cholinergic Signaling 351: Increased Mortality Nov 29, 2016 Dec 3, 2016 None
445 381: BDNF, Reduced 427: Down Regulation, K-Cl co-transporter 2 (KCC2) Nov 29, 2016 Dec 3, 2016 None
446 427: Down Regulation, K-Cl co-transporter 2 (KCC2) 428: Delay, Developmental GABA shift Nov 29, 2016 Dec 3, 2016 None
447 428: Delay, Developmental GABA shift 385: Synaptogenesis, Decreased Nov 29, 2016 Dec 3, 2016 None
449 12: AchE Inhibition 444: Increased, Atrioventricular block and bradycardia Nov 29, 2016 Dec 3, 2016 None
386 145: Induction, IKB inhibitory protein 202: Inhibition, Nuclear factor kappa B (NF-kB) Nov 29, 2016 Dec 3, 2016
399 289: Decrease, Translocator protein (TSPO) 413: Reduction, Testosterone synthesis in Leydig cells Nov 29, 2016 Dec 3, 2016 None
398 416: Increase proliferation, Leydig cell 415: Hyperplasia, Leydig cell Nov 29, 2016 Dec 3, 2016
395 228: demethylation, PPARg promoter 408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) Nov 29, 2016 Dec 3, 2016 None