Key Event Relationships (KERs)

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Showing 176 to 200 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
393 405: disrupted, ovarian cycle 330: Decrease, Fertility Nov 29, 2016 Dec 3, 2016 None
392 219: Reduction, Plasma 17beta-estradiol concentrations 405: disrupted, ovarian cycle Nov 29, 2016 Dec 3, 2016
390 168: Decreased, Lymphocytes 403: Suppression, Immune system Nov 29, 2016 Dec 3, 2016
389 168: Decreased, Lymphocytes 323: Increased, Disease susceptibility Nov 29, 2016 Dec 3, 2016 None
388 152: Suppression, Inflammatory cytokines 168: Decreased, Lymphocytes Nov 29, 2016 Dec 3, 2016
387 202: Inhibition, Nuclear factor kappa B (NF-kB) 152: Suppression, Inflammatory cytokines Nov 29, 2016 Dec 3, 2016
385 122: Increase, GR activation 145: Induction, IKB inhibitory protein Nov 29, 2016 Dec 3, 2016
383 279: Thyroperoxidase, Inhibition 402: Cognitive function, decreased Nov 29, 2016 Dec 3, 2016 None
380 397: Response, Keratinocytes 272: Activation/Proliferation, T-cells Nov 29, 2016 Dec 3, 2016 None
376 396: Covalent Binding, Protein 397: Response, Keratinocytes Nov 29, 2016 Dec 3, 2016 None
368 352: N/A, Neurodegeneration 386: Neuronal network function, Decreased Nov 29, 2016 Dec 3, 2016 None
350 384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci 378: Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Dec 3, 2016 None
344 373: Formation, Pro-mutagenic DNA Adducts 377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H Nov 29, 2016 Dec 3, 2016 None
340 380: Activation, Pre-MIE: Metabolism of AFB1 373: Formation, Pro-mutagenic DNA Adducts Nov 29, 2016 Dec 3, 2016 None
338 310: Alteration, Wnt pathway 240: Feminisation or incomplete development, Primary and accessory male sex organs Nov 29, 2016 Dec 3, 2016
459 10: ACh Synaptic Accumulation 12: AchE Inhibition Nov 29, 2016 Dec 3, 2016
460 446: Reduction of testosterone 414: Increase, Luteinizing hormone (LH) Nov 29, 2016 Dec 3, 2016 None
461 414: Increase, Luteinizing hormone (LH) 416: Increase proliferation, Leydig cell Nov 29, 2016 Dec 3, 2016
462 415: Hyperplasia, Leydig cell 406: decreased, Fertility Nov 29, 2016 Dec 3, 2016
473 18: Activation, AhR 451: Inhibition, Mitochondrial fatty acid beta-oxidation Nov 29, 2016 Dec 3, 2016
475 451: Inhibition, Mitochondrial fatty acid beta-oxidation 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
476 456: Suppression, Constitutive androstane receptor, NR1l3 167: Activation, LXR Nov 29, 2016 Dec 3, 2016
477 456: Suppression, Constitutive androstane receptor, NR1l3 228: demethylation, PPARg promoter Nov 29, 2016 Dec 3, 2016
479 167: Activation, LXR 457: Activation, SREBF1 Nov 29, 2016 Dec 3, 2016
482 457: Activation, SREBF1 458: Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016 None