Key Event Relationships (KERs)

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Showing 201 to 225 of 3130 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
483 66: Activation, ChREBP 458: Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016
484 458: Increased, De Novo FA synthesis 454: Increased, Triglyceride formation Nov 29, 2016 Dec 3, 2016 None
486 454: Increased, Triglyceride formation 459: Increase, Liver steatosis Nov 29, 2016 Dec 3, 2016
487 228: demethylation, PPARg promoter 457: Activation, SREBF1 Nov 29, 2016 Dec 3, 2016
489 457: Activation, SREBF1 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
490 167: Activation, LXR 463: Up Regulation, FAS Nov 29, 2016 Dec 3, 2016
491 167: Activation, LXR 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
492 463: Up Regulation, FAS 458: Increased, De Novo FA synthesis Nov 29, 2016 Dec 3, 2016
493 462: Up Regulation, SCD-1 454: Increased, Triglyceride formation Nov 29, 2016 Dec 3, 2016
495 18: Activation, AhR 54: Up Regulation, CD36 Nov 29, 2016 Dec 3, 2016
496 18: Activation, AhR 465: Increased, FA Influx Nov 29, 2016 Dec 3, 2016 None
499 18: Activation, AhR 216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) Nov 29, 2016 Dec 3, 2016
501 54: Up Regulation, CD36 465: Increased, FA Influx Nov 29, 2016 Dec 3, 2016
503 216: Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
504 465: Increased, FA Influx 291: Accumulation, Triglyceride Nov 29, 2016 Dec 3, 2016 None
505 465: Increased, FA Influx 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
506 18: Activation, AhR 466: Up Regulation, LDLR (low density lipoprotein receptor) Nov 29, 2016 Dec 3, 2016
507 466: Up Regulation, LDLR (low density lipoprotein receptor) 467: Increased, LDL uptake Nov 29, 2016 Dec 3, 2016
508 467: Increased, LDL uptake 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
509 18: Activation, AhR 450: Decrease, VLDL export capacity Nov 29, 2016 Dec 3, 2016
510 167: Activation, LXR 468: Inhibition, PPAR alpha Nov 29, 2016 Dec 3, 2016
511 468: Inhibition, PPAR alpha 451: Inhibition, Mitochondrial fatty acid beta-oxidation Nov 29, 2016 Dec 3, 2016
512 458: Increased, De Novo FA synthesis 327: Accumulation, Fatty acid Nov 29, 2016 Dec 3, 2016
514 327: Accumulation, Fatty acid 454: Increased, Triglyceride formation Nov 29, 2016 Dec 3, 2016
515 327: Accumulation, Fatty acid 459: Increase, Liver steatosis Nov 29, 2016 Dec 3, 2016