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All KERs

Showing 1 to 25 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3797	1635: Increase, DNA strand breaks	55: Cell injury/death	May 12, 2026	May 12, 2026	1 AOP 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death
3706	2393: AR transcriptional activity in GT tissues, reduced	2399: FGF10/FGFR2-IIIb signaling in genital tissue, reduced	Dec 16, 2025	May 7, 2026	1 AOP 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
3746	2294: Plasma E2, increased	2413: Increased, uterine weight	Mar 13, 2026	May 4, 2026	1 AOP 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining
3796	2423: Hepatic SHP, decreased	1421: Activated, LXR	Apr 28, 2026	Apr 28, 2026	1 AOP 232: NFE2/Nrf2 repression to steatosis
3795	2421: FXR inhibition	2423: Hepatic SHP, decreased	Apr 28, 2026	Apr 28, 2026	1 AOP 232: NFE2/Nrf2 repression to steatosis
3794	1417: NFE2/Nrf2 repression	2421: FXR inhibition	Apr 28, 2026	Apr 28, 2026	1 AOP 232: NFE2/Nrf2 repression to steatosis
3793	902: Inflammation, Liver	1489: Increase, Steatohepatitis	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3792	902: Inflammation, Liver	1931: Disruption of the intestinal barrier	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3791	1392: Increase, Oxidative Stress	902: Inflammation, Liver	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3790	2428: PAMPs, increased	1392: Increase, Oxidative Stress	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
403	281: T4 in serum, Decreased	402: Cognitive function, decreased	Nov 29, 2016	Apr 27, 2026	4 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
1506	277: TH synthesis, Decreased	341: Impairment, Learning and memory	May 10, 2017	Apr 27, 2026	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
1503	424: Inhibition, Na+/I- symporter (NIS)	341: Impairment, Learning and memory	May 10, 2017	Apr 27, 2026	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
3789	1931: Disruption of the intestinal barrier	2428: PAMPs, increased	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3788	2427: Bile acid composition, altered	1931: Disruption of the intestinal barrier	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3787	2426: BSEP (ABCB11), decreased	2427: Bile acid composition, altered	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3786	2425: Intrahepatic bile acids, increased	2426: BSEP (ABCB11), decreased	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3785	2424: Hepatic CYP7A1, increased	2425: Intrahepatic bile acids, increased	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3784	2422: Decreased FGF15/FGF19	2424: Hepatic CYP7A1, increased	Apr 27, 2026	Apr 27, 2026	1 AOP 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
3783	1757: Reduce, Sperm count	406: decreased, Fertility	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3782	1890: Germ cell loss, male	1757: Reduce, Sperm count	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3781	1889: premature meiosis, male germ cells	1890: Germ cell loss, male	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3780	2420: Increased, RAR activation	1889: premature meiosis, male germ cells	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3779	1888: increased atRA concentration	2420: Increased, RAR activation	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
3778	1887: CYP26B1, inhibition	1888: increased atRA concentration	Apr 24, 2026	Apr 24, 2026	1 AOP 400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility

Key Event Relationships (KERs)

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