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Showing 2901 to 2925 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1699	151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways	398: Activation, Dendritic Cells	Dec 7, 2017	Dec 3, 2020	None
1411	1303: Activation, HSD17B4	451: Inhibition, Mitochondrial fatty acid beta-oxidation	Apr 12, 2017	Apr 12, 2017	None
1415	1303: Activation, HSD17B4	1312: Increase, Fatty acid β-oxidation	Apr 13, 2017	Apr 13, 2017	None
2985	2162: Activation, HIF1α	2163: Activation Sema6A	Aug 20, 2023	Aug 20, 2023	1 AOP 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
1365	1280: Activation, HIF-1	1262: Apoptosis	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1204	1157: Activation, Hepatic nuclear receptor(s)	1158: Increased, Hepatic thyroid hormone uptake/transport	Nov 29, 2016	Dec 3, 2016	1 AOP 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
1205	1157: Activation, Hepatic nuclear receptor(s)	295: Induction, Upregulation of glucuronyltransferase activity	Nov 29, 2016	Dec 3, 2016	1 AOP 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
1057	1018: Activation, Glutamate-gated chloride channels	761: Increased, Chloride conductance	Nov 29, 2016	Dec 3, 2016	1 AOP 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
3084	1018: Activation, Glutamate-gated chloride channels	388: Overactivation, NMDARs	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3085	1018: Activation, Glutamate-gated chloride channels	2195: Increase, CNS Neural cell death	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
752	760: Activation, Glutamate-gated chloride channel	761: Increased, Chloride conductance	Nov 29, 2016	Dec 3, 2016	1 AOP 113: Glutamate-gated chloride channel activation leading to acute mortality
1407	1304: Activation, FXR	480: Activation, SHP	Apr 12, 2017	Apr 12, 2017	None
1408	1304: Activation, FXR	227: Activation, PPARα	Apr 12, 2017	Apr 12, 2017	None
1381	1293: Activation, FOXO	1294: Inhibition, Wnt pathway	Feb 15, 2017	Feb 15, 2017	1 AOP 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
3590	1293: Activation, FOXO	2347: Increase, Lipid degradation	Aug 16, 2025	Aug 16, 2025	1 AOP 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
133	116: Activation, FAS	89: Synthesis, De Novo Fatty Acid (FA)	Nov 29, 2016	Dec 3, 2016	1 AOP 34: LXR activation leading to hepatic steatosis
1422	116: Activation, FAS	1306: Increase, De novo lipogenesis	Apr 13, 2017	Apr 13, 2017	None
1103	1065: Activation, ERα	1066: Promotion, SIX1 positive progenitor cells in endometrium	Nov 29, 2016	Dec 3, 2016	None
2665	1065: Activation, ERα	1985: Increased Kisspeptin levels in AVPV	Jun 6, 2022	Mar 18, 2026	5 AOPs 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2666	1065: Activation, ERα	1986: Decreased, Gonadotropins	Jun 6, 2022	Aug 15, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
2730	1065: Activation, ERα	1991: Impaired, Reproduction	Aug 15, 2022	Aug 15, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
2969	1065: Activation, ERα	2152: Epigenetic modification process	Jul 27, 2023	Apr 28, 2025	1 AOP 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
3646	1065: Activation, ERα	968: Decreased, release of kisspeptin from AVPV neurons	Oct 2, 2025	Mar 18, 2026	1 AOP 609: Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release
3773	1065: Activation, ERα	2417: Increased, differentiation to ovaries	Apr 17, 2026	Apr 17, 2026	1 AOP 641: Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries
936	913: Activation, Epidermal Growth Factor Receptor	914: Decreased ciliated cell apoptosis	Nov 29, 2016	Dec 3, 2016	None

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