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All KERs

Showing 3026 to 3050 of 3185 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2689	18: Activation, AhR	1559: Smaller and morphologically distorted facial cartilage structures	Jun 30, 2022	Apr 13, 2023	1 AOP 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
2765	18: Activation, AhR	317: Altered, Cardiovascular development/function	Sep 27, 2022	Oct 21, 2022	1 AOP 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
2883	18: Activation, AhR	295: Induction, Upregulation of glucuronyltransferase activity	Apr 12, 2023	Apr 12, 2023	1 AOP 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
2888	18: Activation, AhR	345: N/A, Liver Steatosis	Apr 13, 2023	Apr 13, 2023	None
3219	18: Activation, AhR	459: Increase, Liver steatosis	May 14, 2024	Aug 13, 2026	1 AOP 494: AhR activation leading to liver fibrosis
3482	18: Activation, AhR	1883: Decreased, ovarian reserve	Jan 22, 2025	Jan 22, 2025	None
3533	18: Activation, AhR	2323: Over-expression of PD-L1 in cancer cells	May 16, 2025	Feb 25, 2026	1 AOP 578: AhR activation leading to cancer progression via immunosuppression
3836	18: Activation, AhR	2444: Progesterone resistance	Aug 5, 2026	Aug 5, 2026	1 AOP 577: AhR activation leading to endometriosis
750	9: Activation, 5HT2c	294: N/A, Unknown	Nov 29, 2016	Dec 3, 2016	1 AOP 33: Kidney toxicity induced by activation of 5HT2C
1438	1336: Activation, 5-HT2A	1337: Activate, PLC	Apr 14, 2017	Apr 14, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1375	1288: Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene	1289: Perturbation of cholesterol	Feb 15, 2017	Feb 15, 2017	1 AOP 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
2986	2163: Activation Sema6A	2164: Activation, Dll4-Notch pathway	Aug 20, 2023	Aug 20, 2023	1 AOP 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
2600	1974: Activation of TP53	1365: Increase, Apoptosis	Mar 9, 2022	Mar 9, 2022	None
2601	1974: Activation of TP53	1560: Cell differentiation, altered	Mar 17, 2022	Mar 17, 2022	None
2606	1974: Activation of TP53	1979: Premature differentiation	Mar 21, 2022	Mar 21, 2022	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
3105	1974: Activation of TP53	1262: Apoptosis	Jan 10, 2024	Jan 10, 2024	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
319	288: Activation of specific nuclear receptors, Transcriptional change	357: Cholestasis, Pathology	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
1071	1028: Activation of specific nuclear receptors, PPAR-gamma activation	1029: Increased, adipogenesis	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1072	1028: Activation of specific nuclear receptors, PPAR-gamma activation	1032: Increased, secretion of local growth factors	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1609	1028: Activation of specific nuclear receptors, PPAR-gamma activation	1449: increased adipogenesis	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis
3711	1028: Activation of specific nuclear receptors, PPAR-gamma activation	202: Inhibition, Nuclear factor kappa B (NF-kB)	Jan 16, 2026	Jan 16, 2026	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
1720	1507: Activation of PPARγ	149: Increase, Inflammation	Mar 18, 2018	Mar 18, 2018	None
3697	1507: Activation of PPARγ	202: Inhibition, Nuclear factor kappa B (NF-kB)	Dec 3, 2025	Dec 3, 2025	None
3816	1507: Activation of PPARγ	2441: Increased fatty acid synthesis and transport	Jul 9, 2026	Jul 9, 2026	1 AOP 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
3818	1507: Activation of PPARγ	1824: Decrease, FAO	Jul 9, 2026	Jul 9, 2026	1 AOP 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders

Key Event Relationships (KERs)

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