Key Event Relationships (KERs)

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Showing 3026 to 3050 of 3129 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1559 1421: Activated, LXR 1422: Reduced, PPARalpha Jun 2, 2017 Jun 2, 2017
3013 2172: Activated Wnt/Frizzled pathway 2161: Increase, Vascular disrupting effects Aug 21, 2023 Aug 21, 2023 None
3022 2172: Activated Wnt/Frizzled pathway 1928: increased，Vascular endothelial dysfunction Aug 21, 2023 Aug 21, 2023
3012 2171: Activated BMP/TGF-beta pathway 2161: Increase, Vascular disrupting effects Aug 21, 2023 Aug 21, 2023 None
3021 2171: Activated BMP/TGF-beta pathway 1928: increased，Vascular endothelial dysfunction Aug 21, 2023 Aug 21, 2023
3010 2170: Activated ANG/Tie2 pathway 2161: Increase, Vascular disrupting effects Aug 21, 2023 Aug 21, 2023 None
3020 2170: Activated ANG/Tie2 pathway 1928: increased，Vascular endothelial dysfunction Aug 21, 2023 Aug 21, 2023
3015 2173: Activated AKT/ERK/PI3K pathway 2161: Increase, Vascular disrupting effects Aug 21, 2023 Aug 21, 2023 None
3024 2173: Activated AKT/ERK/PI3K pathway 1928: increased，Vascular endothelial dysfunction Aug 21, 2023 Aug 21, 2023
1461 1360: Activate, presynaptic neuron 2 1361: Increase, GABA Apr 14, 2017 Apr 14, 2017
1439 1337: Activate, PLC 1338: Increase, inositol triphosphate Apr 14, 2017 Apr 14, 2017
1488 1383: Activate, phospholipase 1382: Decrease, surfactant Apr 17, 2017 Apr 17, 2017
1475 1380: Activate, mucosal defense 1367: Inhibit, gastric ulcer formation Apr 17, 2017 Apr 17, 2017
1476 1379: Activate, leukocyte 1385: Activated, gastric ulcer formation Apr 17, 2017 Apr 17, 2017
1464 1359: Activate, GABA-A receptor 1322: Increased, intracellular chloride (Cl-) Apr 14, 2017 Apr 14, 2017
1442 1340: Activate, calmodulin 1341: Increase, myosin light chain phosphorylation Apr 14, 2017 Apr 14, 2017
2032 1724: Acinar cell proliferation 1725: Acinar cell tumors Jan 8, 2020 Jan 8, 2020
11 12: AchE Inhibition 10: ACh Synaptic Accumulation Nov 29, 2016 Sep 10, 2023
449 12: AchE Inhibition 444: Increased, Atrioventricular block and bradycardia Nov 29, 2016 Dec 3, 2016 None
450 12: AchE Inhibition 445: Respiratory distress/arrest Nov 29, 2016 Dec 20, 2019
451 12: AchE Inhibition 39: Increased Cholinergic Signaling Nov 29, 2016 Dec 20, 2019
452 12: AchE Inhibition 351: Increased Mortality Nov 29, 2016 Dec 20, 2019
453 12: AchE Inhibition 442: Decreased, Population trajectory Nov 29, 2016 Dec 20, 2019 None
2007 12: AchE Inhibition 1703: Cardiovascular dysregulation Nov 25, 2019 Dec 20, 2019
2014 12: AchE Inhibition 1705: Impaired coordination and movement Dec 20, 2019 Dec 20, 2019