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Showing 3101 to 3125 of 3131 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

17	17: Altered expression of AHR/ARNT pathway-dependent genes	80: Up Regulation, CYP1A1	Nov 29, 2016	Dec 3, 2016	None
16	17: Altered expression of AHR/ARNT pathway-dependent genes	317: Altered, Cardiovascular development/function	Nov 29, 2016	Dec 3, 2016	None
11	12: AchE Inhibition	10: ACh Synaptic Accumulation	Nov 29, 2016	Sep 10, 2023	4 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
9	8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity	179: Decrease, Fatty acid β-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
359	386: Neuronal network function, Decreased	341: Impairment, Learning and memory	Nov 29, 2016	Jul 15, 2022	6 AOPs 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
360	387: Binding of agonist, NMDARs	388: Overactivation, NMDARs	Nov 29, 2016	Nov 29, 2016	None
361	388: Overactivation, NMDARs	389: Increased, Intracellular Calcium overload	Nov 29, 2016	Sep 10, 2023	4 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
362	389: Increased, Intracellular Calcium overload	177: Increase, Mitochondrial dysfunction	Nov 29, 2016	Nov 29, 2016	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
363	177: Increase, Mitochondrial dysfunction	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	4 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction
364	55: Cell injury/death	352: N/A, Neurodegeneration	Nov 29, 2016	Sep 10, 2023	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration
365	55: Cell injury/death	188: Neuroinflammation	Nov 29, 2016	Jul 15, 2022	3 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
348	381: BDNF, Reduced	382: Aberrant, Dendritic morphology	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
358	385: Synaptogenesis, Decreased	386: Neuronal network function, Decreased	Nov 29, 2016	May 25, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
357	383: Reduced, Presynaptic release of glutamate	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
356	382: Aberrant, Dendritic morphology	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
355	55: Cell injury/death	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
354	381: BDNF, Reduced	383: Reduced, Presynaptic release of glutamate	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
353	381: BDNF, Reduced	55: Cell injury/death	Nov 29, 2016	Nov 29, 2016	2 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
352	373: Formation, Pro-mutagenic DNA Adducts	384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci	Nov 29, 2016	Nov 29, 2016	None
351	376: Increased, Induced Mutations in Critical Genes	384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci	Nov 29, 2016	Nov 29, 2016	None
350	384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Dec 3, 2016	None
336	307: Increase, Vitellogenin synthesis in liver	220: Increase, Plasma vitellogenin concentrations	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
347	52: Decreased, Calcium influx	381: BDNF, Reduced	Nov 29, 2016	Jun 13, 2018	2 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
346	376: Increased, Induced Mutations in Critical Genes	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Nov 30, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
345	373: Formation, Pro-mutagenic DNA Adducts	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Nov 29, 2016	1 AOP 46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)

Key Event Relationships (KERs)

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