Key Event Relationships (KERs)

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Showing 376 to 400 of 3129 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2516 1947: Pericyte dysfunction 1913: Endothelial cell dysfunction Oct 28, 2021 Oct 28, 2021 None
236 209: Peptide Oxidation 134: Increase, Kupffer cell activation Nov 29, 2016 Dec 3, 2016 None
764 209: Peptide Oxidation 719: Increase, hepatocellular adenomas and carcinomas Nov 29, 2016 Dec 3, 2016 None
765 209: Peptide Oxidation 768: Increase, Cytotoxicity Nov 29, 2016 Dec 3, 2016
922 209: Peptide Oxidation 177: Increase, Mitochondrial dysfunction Nov 29, 2016 Nov 29, 2016 None
923 209: Peptide Oxidation 87: Release, Cytokine Nov 29, 2016 Dec 3, 2016 None
932 209: Peptide Oxidation 357: Cholestasis, Pathology Nov 29, 2016 Dec 3, 2016
948 209: Peptide Oxidation 926: Oxidation, Glutathione Nov 29, 2016 Nov 29, 2016 None
980 209: Peptide Oxidation 935: Decrease, GTPCH-1 Nov 29, 2016 Sep 28, 2017
992 209: Peptide Oxidation 973: Decrease, AKT/eNOS activity Nov 29, 2016 Oct 16, 2017
1237 209: Peptide Oxidation 1172: Increased activation, Nuclear factor kappa B (NF-kB) Nov 29, 2016 Dec 3, 2016 None
1379 209: Peptide Oxidation 1292: Activation, JNK Feb 15, 2017 Feb 15, 2017
1467 209: Peptide Oxidation 1194: Increase, DNA Damage Apr 15, 2017 Apr 15, 2017 None
1698 209: Peptide Oxidation 927: S-Glutathionylation, eNOS Nov 16, 2017 Nov 20, 2017
3083 896: Parkinsonian motor deficits 350: Increase, Mortality Oct 17, 2023 Oct 17, 2023
1711 1504: p21 (CDKN1A) expression, increase 1505: Cell cycle, disrupted Jan 21, 2018 Jul 25, 2018 None
1282 1231: Oxidization of biomolecules, Lipid bilayer and cellular proteins 1215: TRPA1 activation, TRPA1 Receptor Nov 29, 2016 Dec 3, 2016 None
1285 1231: Oxidization of biomolecules, Lipid bilayer and cellular proteins 1236: Generation of novel epitopes , Antigen presentation Nov 29, 2016 Dec 3, 2016 None
1286 1231: Oxidization of biomolecules, Lipid bilayer and cellular proteins 1234: Production of nerve growth factor , Epithelial irritation Nov 29, 2016 Dec 3, 2016 None
1669 1477: OXPHOS, decreased 40: Mitochondrial ATP production, decreased Oct 10, 2017 Oct 10, 2017
1810 1477: OXPHOS, decreased 1562: Decreased Na/K ATPase activity Dec 20, 2018 Dec 20, 2018
2095 1477: OXPHOS, decreased 1771: Decrease, ATP pool Apr 30, 2020 Apr 30, 2020
2346 1477: OXPHOS, decreased 1808: Decrease, ATP synthase activity Apr 11, 2021 Apr 11, 2021 None
2713 1477: OXPHOS, decreased 1392: Increase, Oxidative Stress Jul 25, 2022 Jul 25, 2022 None
1851 1595: Oxidation/denatuation of membrane proteins 1599: Inflammatory events Feb 4, 2019 Jul 9, 2019