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Showing 1301 to 1325 of 3129 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2070	1754: Increase, porcupine-induced Wnt secretion and Wnt signaling activation	1755: beta-catenin activation	Mar 23, 2020	Nov 9, 2021	1 AOP 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
2555	1965: Increase, Pollen abnormal	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 435: Deposition of ionising energy leads to population decline via pollen abnormal
1474	1375: Increase, platelet aggregation	1367: Inhibit, gastric ulcer formation	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
254	220: Increase, Plasma vitellogenin concentrations	252: Increase, Renal pathology due to VTG deposition	Nov 29, 2016	Jun 24, 2024	2 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
3259	220: Increase, Plasma vitellogenin concentrations	364: Impaired development of, Reproductive organs	Jul 3, 2024	Jul 3, 2024	1 AOP 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
2409	1892: increase, placental insufficiency	1893: increase, Preeclampsia	May 31, 2021	May 31, 2021	1 AOP 151: AhR activation leading to preeclampsia
1230	1170: Increase, Phenotypic enzyme activity	716: Increase, cell proliferation (hepatocytes)	Nov 29, 2016	Dec 31, 2020	1 AOP 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
1231	1170: Increase, Phenotypic enzyme activity	1171: Increase, Clonal Expansion of Altered Hepatic Foci	Nov 29, 2016	Dec 3, 2016	None
1241	1173: Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
3552	2337: Increase, PLIN2	2333: Increase, Fat mass	Jul 25, 2025	Jul 25, 2025	1 AOP 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
2340	1865: Increase, OEC damage	1862: Decrease, Photosystem II efficiency	Apr 11, 2021	Apr 11, 2021	1 AOP 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1362	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1281: Increased, DNA Damage-Repair	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1364	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1280: Activation, HIF-1	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
3166	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	177: Increase, Mitochondrial dysfunction	Mar 14, 2024	Mar 14, 2024	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
3512	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1115: Increase, ROS	Apr 3, 2025	Apr 3, 2025	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1513	1392: Increase, Oxidative Stress	1393: Hepatocytotoxicity	May 30, 2017	Jun 19, 2021	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer
1516	1392: Increase, Oxidative Stress	1395: Liver Cancer	May 30, 2017	Jun 19, 2021	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer
1685	1392: Increase, Oxidative Stress	1488: Glutamate dyshomeostasis	Nov 9, 2017	Feb 6, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1690	1392: Increase, Oxidative Stress	55: Cell injury/death	Nov 9, 2017	Feb 7, 2020	4 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress
2008	1392: Increase, Oxidative Stress	1645: Wnt ligand stimulation	Dec 3, 2019	Dec 3, 2019	None
2289	1392: Increase, Oxidative Stress	1845: Coagulation	Mar 25, 2021	Mar 25, 2021	None
2449	1392: Increase, Oxidative Stress	1906: CFTR Function, Decreased	Jul 30, 2021	Sep 28, 2021	1 AOP 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
2450	1392: Increase, Oxidative Stress	1911: FOXJ1 Protein, Decreased	Aug 2, 2021	Sep 28, 2021	1 AOP 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
2451	1392: Increase, Oxidative Stress	1908: CBF, Decreased	Aug 2, 2021	Mar 24, 2023	1 AOP 411: Oxidative stress Leading to Decreased Lung Function
2505	1392: Increase, Oxidative Stress	1943: p-Tau	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants

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