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Showing 1301 to 1325 of 3185 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2339	1864: Increase, Programmed cell death	1479: Decrease, Leaf development	Apr 11, 2021	Apr 11, 2021	None
2553	1864: Increase, Programmed cell death	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 388: Deposition of ionising energy leading to population decline via programmed cell death
3835	2444: Progesterone resistance	149: Increase, Inflammation	Aug 4, 2026	Aug 4, 2026	1 AOP 577: AhR activation leading to endometriosis
2835	2097: Increase, Pro-Inflammatory Mediators	2098: Abnormal Neural Remodeling	Jan 25, 2023	Sep 10, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
2839	2097: Increase, Pro-Inflammatory Mediators	341: Impairment, Learning and memory	Jan 25, 2023	Jul 26, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment
774	774: Increase, Preneoplastic foci (hepatocytes)	719: Increase, hepatocellular adenomas and carcinomas	Nov 29, 2016	Feb 15, 2017	3 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
1744	1524: Increase, Premature molting	350: Increase, Mortality	May 24, 2018	Feb 17, 2021	5 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
2634	623: Increase, predation	360: Decrease, Population growth rate	Apr 6, 2022	Apr 6, 2022	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
2070	1754: Increase, porcupine-induced Wnt secretion and Wnt signaling activation	1755: beta-catenin activation	Mar 23, 2020	Nov 9, 2021	1 AOP 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
2555	1965: Increase, Pollen abnormal	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 435: Deposition of ionising energy leads to population decline via pollen abnormal
1474	1375: Increase, platelet aggregation	1367: Inhibit, gastric ulcer formation	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
254	220: Increase, Plasma vitellogenin concentrations	252: Increase, Renal pathology due to VTG deposition	Nov 29, 2016	Jun 24, 2024	2 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
3259	220: Increase, Plasma vitellogenin concentrations	364: Impaired development of, Reproductive organs	Jul 3, 2024	Jul 3, 2024	1 AOP 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
2409	1892: increase, placental insufficiency	1893: increase, Preeclampsia	May 31, 2021	May 31, 2021	1 AOP 151: AhR activation leading to preeclampsia
1230	1170: Increase, Phenotypic enzyme activity	716: Increase, cell proliferation (hepatocytes)	Nov 29, 2016	Dec 31, 2020	1 AOP 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
1231	1170: Increase, Phenotypic enzyme activity	1171: Increase, Clonal Expansion of Altered Hepatic Foci	Nov 29, 2016	Dec 3, 2016	None
1241	1173: Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
3552	2337: Increase, PLIN2	2333: Increase, Fat mass	Jul 25, 2025	Jul 25, 2025	1 AOP 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
2340	1865: Increase, OEC damage	1862: Decrease, Photosystem II efficiency	Apr 11, 2021	Apr 11, 2021	1 AOP 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1362	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1281: Increased, DNA Damage-Repair	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1364	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1280: Activation, HIF-1	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
3166	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	177: Increase, Mitochondrial dysfunction	Mar 14, 2024	Mar 14, 2024	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
3512	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1115: Increase, ROS	Apr 3, 2025	Apr 3, 2025	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1513	1392: Increase, Oxidative Stress	1393: Hepatocytotoxicity	May 30, 2017	Jun 19, 2021	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer
1516	1392: Increase, Oxidative Stress	1395: Liver Cancer	May 30, 2017	Jun 19, 2021	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer

Key Event Relationships (KERs)

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