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Showing 2051 to 2075 of 3185 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

520	472: Down Regulation, CPT1A	179: Decrease, Fatty acid β-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
1497	1388: Dopamine release in the brain, decreased	1389: Locomotor activity, decreased	May 2, 2017	May 2, 2017	1 AOP 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
1502	1388: Dopamine release in the brain, decreased	1390: Sexual behavior, decreased	May 9, 2017	May 9, 2017	1 AOP 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
843	831: Disturbance, Lysosomal function	833: Occurrence, Cytoplasmic vacuolization (hepatocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
844	831: Disturbance, Lysosomal function	835: Occurrence, Ballooning degeneration (hepatocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
845	831: Disturbance, Lysosomal function	836: Occurrence, Cytoplasmic vacuolization (Bile duct cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
846	831: Disturbance, Lysosomal function	837: Occurrence, Cytoplasmic vacuolization (kupffer cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
1678	831: Disturbance, Lysosomal function	898: Disruption, Lysosome	Oct 25, 2017	Oct 25, 2017	1 AOP 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
1834	1581: Disturbance in microtubule dynamic instability	1582: Impaired axonial transport	Jan 29, 2019	Jan 29, 2019	1 AOP 279: Microtubule interacting drugs lead to peripheral neuropathy
1842	1590: Distribution of chemicals	1591: Absorption of photon energy	Feb 4, 2019	Feb 4, 2019	None
1762	1537: Disruption, Sarcomere assembly	1532: Decrease, Cardiac contractility	Jun 21, 2018	Jun 21, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
2562	1682: Disruption, Progenitor cells of second heart field	1557: Reduced neural crest cell migration	Feb 8, 2022	Feb 10, 2022	1 AOP 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
2955	2151: Disruption, neurotransmitter release	341: Impairment, Learning and memory	Jun 27, 2023	Apr 11, 2024	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 535: Binding and activation of GPER leading to learning and memory impairments
3080	2151: Disruption, neurotransmitter release	637: impaired, Learning and memory	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3458	2151: Disruption, neurotransmitter release	2301: Abnormal, Behavior	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
715	720: Disruption, Microtubule dynamics	721: Disorganization, Meiotic Spindle	Nov 29, 2016	Dec 13, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
921	898: Disruption, Lysosome	209: Peptide Oxidation	Nov 29, 2016	Nov 29, 2016	None
993	898: Disruption, Lysosome	177: Increase, Mitochondrial dysfunction	Nov 29, 2016	Nov 12, 2018	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
1679	898: Disruption, Lysosome	709: Increase, Cytotoxicity (renal tubular cell)	Oct 25, 2017	Oct 25, 2017	1 AOP 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
1761	1536: Disruption, Intracellular calcium mobilization	1537: Disruption, Sarcomere assembly	Jun 21, 2018	Jun 21, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
3457	2300: Disruption, Glucolipid metabolism	566: impaired, Larval development	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
3242	1983: Disruption in action potential generation	2005: neurotrasmission in development	Jun 3, 2024	Jul 31, 2024	1 AOP 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
3404	1983: Disruption in action potential generation	2280: Prolonged atrioventricular (AV)	Nov 20, 2024	Nov 20, 2024	1 AOP 551: Increased Muscarinic M2 Receptor leading to Arrhythmia
3668	2379: Disruption, regulatory function of dopamine signaling components.	2380: Increase, dopamine transporter gene	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3669	2379: Disruption, regulatory function of dopamine signaling components.	2381: Increase, dopamine receptor gene	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes

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