AOP-Wiki

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All KERs

Showing 2101 to 2125 of 3185 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2683	944: dimerization, AHR/ARNT	2021: Increase, slincR expression	Jun 30, 2022	Sep 8, 2022	2 AOPs 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
3466	944: dimerization, AHR/ARNT	2124: increased, Bax	Jan 4, 2025	May 27, 2025	1 AOP 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
3381	2273: Dihydrotestosterone (DHT) levels, increased	2274: Androgen receptor activation, increased	Nov 2, 2024	Nov 24, 2024	None
659	663: Desensitization, Nicotinic acetylcholine receptor	386: Neuronal network function, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
1309	663: Desensitization, Nicotinic acetylcholine receptor	1243: Altered, Ca2+-calmodulin activated signal transduction	Nov 29, 2016	Dec 3, 2016	2 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
1798	1550: Ionizing Energy	1553: Increase mutations	Dec 19, 2018	Dec 19, 2018	None
1799	1550: Ionizing Energy	1554: Increase chromosomal aberrations	Dec 19, 2018	Dec 19, 2018	None
2379	1550: Ionizing Energy	1115: Increase, ROS	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2380	1550: Ionizing Energy	1194: Increase, DNA Damage	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2392	1550: Ionizing Energy	752: Altered, Meiotic chromosome dynamics	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2393	1550: Ionizing Energy	1798: Decreased spermatogenesis	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2394	1550: Ionizing Energy	406: decreased, Fertility	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2395	1550: Ionizing Energy	1696: Decrease of egg production and cummulative fecundity	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2396	1550: Ionizing Energy	997: Decreased, Population size	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2397	1550: Ionizing Energy	1775: Increase, Oocyte apoptosis	May 14, 2021	May 14, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
3240	1550: Ionizing Energy	1392: Increase, Oxidative Stress	May 31, 2024	May 31, 2024	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
1977	1686: Energy Deposition	1635: Increase, DNA strand breaks	Aug 26, 2019	Jul 29, 2024	6 AOPs 272: Deposition of energy leading to lung cancer 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 478: Deposition of energy leading to occurrence of cataracts 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment
1981	1686: Energy Deposition	185: Increase, Mutations	Aug 29, 2019	Dec 17, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1982	1686: Energy Deposition	1636: Increase, Chromosomal aberrations	Aug 29, 2019	Dec 17, 2024	2 AOPs 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts
1983	1686: Energy Deposition	1556: Increase, lung cancer	Aug 29, 2019	Jul 5, 2023	1 AOP 272: Deposition of energy leading to lung cancer
2548	1686: Energy Deposition	1115: Increase, ROS	Jan 21, 2022	Jan 21, 2022	4 AOPs 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2552	1686: Energy Deposition	1194: Increase, DNA Damage	Jan 21, 2022	Jan 21, 2022	4 AOPs 388: Deposition of ionising energy leading to population decline via programmed cell death 435: Deposition of ionising energy leads to population decline via pollen abnormal 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2604	1686: Energy Deposition	1978: Microcephaly	Mar 17, 2022	Mar 17, 2022	1 AOP 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
2616	1686: Energy Deposition	1632: Increase in RONS	Mar 28, 2022	Mar 28, 2022	2 AOPs 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2769	1686: Energy Deposition	1392: Increase, Oxidative Stress	Sep 28, 2022	Aug 26, 2024	4 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment 482: Deposition of energy leading to occurrence of bone loss 478: Deposition of energy leading to occurrence of cataracts

Key Event Relationships (KERs)

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